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High frequency of G to A transition mutation in the stromal cell derived factor-1 gene in India, a chemokine that blocks HIV-1 (X4) infection: multiple proteins bind to 3′-untranslated region of SDF-1 RNA

Genes & Immunity volume 2, pages 408–410 (2001)Cite this article

Abstract

It has become clear that mutations in a variety of host genes possess the ability to influence the progression of HIV-1, prominent among them are the chemokines. Stromal cell derived factor-1 (SDF-1), an α-chemokine, is a natural ligand for HIV-1 coreceptor-CXCR4 and a potent chemokine that blocks infection by X4 viruses. Nucleotide G to A transition (nucleotide position 801 with respect to the ATG initiation codon) in the 3′-untranslated region of SDF-1 RNA is implicated in having disease-modifying effects. We have screened 100 normal healthy individuals from north India where HIV-1 is spreading at an alarming rate. This mutation is present in 40% (40 out of 100) individuals, 32% being heterozygous and 8% being homozygous for this mutation. This mutation showed Mendelian inheritance in one of the families studied. This observation could be important in understanding the progression or pathogenesis of HIV-1 in India. We also show that multiple proteins bind in the 3′-untranslated region of the SDF-1 RNA.

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Authors and Affiliations

  1. Laboratory of Virology, National Institute of Immunology, JNU Campus, Aruna Asaf Ali Marg, -110067, New Delhi, India

    N Ramamoorti, J Kumarvelu, GK Shanmugasundaram, K Rani & AC Banerjea

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  1. N Ramamoorti
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  2. J Kumarvelu
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  3. GK Shanmugasundaram
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  4. K Rani
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  5. AC Banerjea
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Correspondence to AC Banerjea.

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This work was supported by a grant from the Department of Biotechnology, Government of India, to the National Institute of Immunology, New Delhi, India, and to the corresponding author (ACB).

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Ramamoorti, N., Kumarvelu, J., Shanmugasundaram, G. et al. High frequency of G to A transition mutation in the stromal cell derived factor-1 gene in India, a chemokine that blocks HIV-1 (X4) infection: multiple proteins bind to 3′-untranslated region of SDF-1 RNA . Genes Immun 2, 408–410 (2001). https://doi.org/10.1038/sj.gene.6363800

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  • DOI: https://doi.org/10.1038/sj.gene.6363800

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