Abstract
IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position −1055. The IL-13 −1055 TT genotype is associated with allergic asthma (P = 0.002), altered regulation of IL-13 production (P < 0.002), and increased binding of nuclear proteins to this region. we postulate that the presence of this polymorphism predisposes to the development of allergic asthma.
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This study is financially supported by the Netherlands Asthma Foundation, grant No. 96.42.
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van der Pouw Kraan, T., van Veen, A., Boeije, L. et al. An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun 1, 61–65 (1999). https://doi.org/10.1038/sj.gene.6363630
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DOI: https://doi.org/10.1038/sj.gene.6363630