Abstract
Clinical and epidemiological studies suggest that premature ageing and increased morbidity and mortality is present in Ullrich-Turner syndrome. We studied telomere restriction fragment length (TRFL) in 30 women with Ullrich-Turner syndrome and 30 age-matched control women. All Turner women had the 45,X karyotype verified by karyotyping. We found no difference in the mean TRFL in the young age group (TS: 7011±521 vs C: 7285±917 bp, P = 0.3), or in the older age group (TS: 7357±573 vs C: 7221±621 bp, P = 0.6). In conclusion, our data suggest that Ullrich-Turner syndrome is not associated with excessive telomere loss, at least when studied in peripheral blood leucocytes, and thus quite different from other premature ageing syndromes.
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Kveiborg, M., Gravholt, C. & Kassem, M. Evidence of a normal mean telomere fragment length in patients with Ullrich-Turner syndrome. Eur J Hum Genet 9, 877–879 (2001). https://doi.org/10.1038/sj.ejhg.5200722
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DOI: https://doi.org/10.1038/sj.ejhg.5200722
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