Abstracts on this page have been chosen and edited by Dr Trevor Watts
Abstract
Topical hyaluronic acid (HA) significantly reduced ulceration.
Main
Nolan A, Baillie C et al. J Oral Pathol Med 2006; 35: 461–465
Recurrent aphthous ulceration (RAU), when unrelated to systemic conditions, may cause significant discomfort. In a UK dental hospital, 120 patients presenting with discomfort from RAU were randomised to HA or placebo gel for its relief. Up to 4 hrs after initial gel application by a clinician, levels of discomfort were recorded, and patients were given a diary to keep for 7 days, and a supply of the appropriate gel.
A significant reduction in soreness was shown in both active and placebo groups, lasting about 30 minutes before gradual return of discomfort, but there was no difference between treatments. A significant reduction in ulcers was noted in both groups after application, and there was a difference in favour of the active gel 4 days after. The authors consider the reductions in discomfort to be a barrier effect irrespective of HA, but conclude that this substance may have a clinical advantage of reducing the number of ulcers.
Rights and permissions
About this article
Cite this article
The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration. Br Dent J 201, 765 (2006). https://doi.org/10.1038/sj.bdj.4814361
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bdj.4814361