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Abstract
This study adds further information towards predicting aggressive behaviour of central giant cell granuloma (CGCG).
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Kruse-Lösler B, Diallo R et al. Oral Surg 2006; 101: 346–354
CGCG is a rare lesion, behaving in a way which is often unpredictable, varying from a slowly swelling to a highly aggressive, painful lesion. Opinions differ on whether it is neoplastic or reactive. This study was a retrospective examination of 26 patients with CGCG seen in a German hospital over a 24 year period. The lesions were classified as non-aggressive (NA; mean age and range: 8.6 yrs, 4.8-14.0) or aggressive (A; 15.3, 6.0-57.4), and their characteristics compared.
Females accounted for 2/3 of all cases, and 2/3 also were in the mandible. Group A lesions appeared much larger at diagnosis (mean diameter 56 v. 33 mm). In group A, pain, rapid growth, root resorption and displacement were common; in group NA, these features did not occur. There were no recurrences in group NA, but 4 in group A. Surgical removal was undertaken in all cases: curettage in 5 cases, curettage with ostectomy in 20, and extra-oral block resection in one. The authors consider that the clinical and histological features may help predict the behaviour of the lesions.
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Central giant cell granuloma of the jaws: a clinical, radiologic and histopathologic study of 26 cases. Br Dent J 200, 563 (2006). https://doi.org/10.1038/sj.bdj.4813677
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DOI: https://doi.org/10.1038/sj.bdj.4813677