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Dodson TB J Oral Maxillofac Surg 2005; 63: 891–896

Some patients are at high risk of 2nd molar (M2) periodontal defects after 3rd molar (M3) removal. In this study, 12 such patients (mean age 30 yrs, 3 tobacco smokers) with 18 such M3s were randomised to 3 categories in an original cohort of 27 subjects: DBP in the extraction wound, resorbable guided tissue regeneration (GTR) membrane placed over the socket, or control. Probing attachment level (PAL) on the distal of M2 was evaluated up to 26 weeks postoperatively.

Preoperatively, mean PAL in mm was 6.8 for controls, 5.4 for GTR and 7.6 for DBP (P = 0.43). Respective 26 week scores were: 3.8, 3.0 and 1.4 (P = 0.002). The differences between GTR and DBP and between DBP and control were significant, but not that between GTR and control. The author draws attention to the small sample and possible selection bias in the study.