Having three copies of chromosome 21 reduces the incidence of solid tumours in people with Down's syndrome. Studies in mice provide clues to why, and highlight a complex gene–function relationship.
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Threadgill, D. Paradox of a tumour repressor. Nature 451, 21–22 (2008). https://doi.org/10.1038/451021a
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DOI: https://doi.org/10.1038/451021a
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