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The association between body size, prostate volume and prostate-specific antigen

Prostate Cancer and Prostatic Diseases volume 10, pages 137–142 (2007)Cite this article

Abstract

Increasing prostate volume contributes to urinary tract symptoms and may obscure prostate cancer detection. We investigated the association between obesity and prostate volume, prostate-specific antigen (PSA) and PSA density among 753 men referred for prostate biopsy. Among men with a negative biopsy, prostate volume significantly increased approximately 25% from the lowest to highest body mass index (BMI), waist or hip circumference or height categories. PSA was 0.7 ng/ml lower with a high waist-to-hip ratio. These associations were less consistent among subjects diagnosed with high-grade prostatic intraepithelial neoplasia or cancer. Our data suggest that obesity and height are independently associated with prostate volume.

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Acknowledgements

Funding was provided by the NIH CA98348, DAMD17-02-1-0139 and M01 RR00095 to the Vanderbilt General Clinical Research Center. We are grateful to Dr C Eckstein and the clinical and nursing staff at the Urology Associates, the Veterans Administration and Vanderbilt, for essential collaboration on this project.

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Authors and Affiliations

  1. Division of Internal Medicine and Public Health, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA

    J H Fowke & S S Motley

  2. Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA

    M S Cookson, R Concepcion, S S Chang & J A Smith Jr

  3. Urology Associates, Nashville, TN, USA

    R Concepcion

  4. Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA

    M L Wills

Authors
  1. J H Fowke
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  2. S S Motley
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  3. M S Cookson
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  4. R Concepcion
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  5. S S Chang
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  6. M L Wills
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  7. J A Smith Jr
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Correspondence to J H Fowke.

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The authors state no conflict of interest.

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Fowke, J., Motley, S., Cookson, M. et al. The association between body size, prostate volume and prostate-specific antigen. Prostate Cancer Prostatic Dis 10, 137–142 (2007). https://doi.org/10.1038/sj.pcan.4500924

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  • DOI: https://doi.org/10.1038/sj.pcan.4500924

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