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Prostate-specific antigen adjusted for total prostatic tumor volume as a predictor for outcome after radical prostatectomy

Prostate Cancer and Prostatic Diseases volume 10, pages 60–65 (2007)Cite this article

Abstract

The aim of this study was to investigate the potential prognostic value of preoperative serum prostate-specific antigen levels adjusted for total tumor volume (PSA-TTV density) for outcome following radical prostatectomy for prostate cancer by retrospective review in 268 patients. Lower PSA-TTV density was not only associated with a significantly higher risk for biological failure (bF), systemic failure and cancer death but also an independent predictor for bF (hazard ratio, 6.3). Therefore, these data suggest that there are subsets of prostate cancer with lower PSA secretion levels, and this phenotype is associated with a higher risk of failure after surgery.

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Acknowledgements

We thank WA Thomasson, PhD, for expert editorial assistance.

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Authors and Affiliations

  1. Department of Urology, Jikei University School of Medicine, Minato-ku, Tokyo, Japan

    N Hayashi, I Ikemoto, H Kuruma & S Egawa

  2. Division of Clinical Research and Development, Jikei University School of Medicine, Minato-ku, Tokyo, Japan

    M Urashima

  3. Department of Urology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan

    Y Arai

  4. Department of Pathology, Higashi-Yamato Hospital, Higashi-Yamato, Tokyo, Japan

    S Kuwao

  5. Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan

    S Baba

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  1. N Hayashi
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  2. M Urashima
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  7. S Baba
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  8. S Egawa
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Correspondence to N Hayashi.

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Hayashi, N., Urashima, M., Ikemoto, I. et al. Prostate-specific antigen adjusted for total prostatic tumor volume as a predictor for outcome after radical prostatectomy. Prostate Cancer Prostatic Dis 10, 60–65 (2007). https://doi.org/10.1038/sj.pcan.4500902

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  • DOI: https://doi.org/10.1038/sj.pcan.4500902

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