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Role of transrectal ultrasound guided salvage cryosurgery for recurrent prostate carcinoma after radiotherapy

Prostate Cancer and Prostatic Diseases volume 8, pages 235–242 (2005)Cite this article

Abstract

Despite improvements in treatment of localized prostate cancer, local recurrence remains a significant problem. A total of 46 patients with proven local cancer recurrence following external beam radiotherapy entered a prospective clinical trial using ultrasound-guided cryosurgery to ablate the residual prostate gland. Persistent complications included one urethra–rectal fistula, incontinence (2), retention (3), and treatment induced erectile dysfunction (7). Using the PSA definitions for biochemical failure as PSA ⩾0.3 ng/ml, the Kaplan–Meier plots showed the incidence of patients to be free of biochemical recurrence at 51 and 44% at 1 and 2 y, respectively. For a PSA ⩾1.0, the values at 1 and 2 y were 72 and 58%.

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Acknowledgements

This research was supported by a grant from the Alberta Cancer Board.

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Authors and Affiliations

  1. Departments of Surgery and Oncology, University of Calgary, Calgary Regional Health Authority, Calgary, Alberta, Canada

    B J Donnelly

  2. Department of Urology, Calgary Regional Health Authority, Calgary, Alberta, Canada

    B J Donnelly

  3. Department of Radiology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada

    J C Saliken & J Rewcastle

  4. Department of Diagnostic Radiology, Calgary Regional Health Authority, Calgary, Alberta, Canada

    J C Saliken

  5. Departments of Medicine, Division of Medical Oncology and Internal Medicine, Tom Baker Cancer Centre, and University of Calgary, Calgary, Alberta, Canada

    D S Ernst

  6. Department of Urology, University of Toronto, Ontario, Canada

    B Weber

  7. Department of Oncology and Program in Clinical Psychology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada

    J W Robinson

  8. Department of Psychosocial Resources, Tom Baker Cancer Centre, Calgary, Alberta, Canada

    J W Robinson

  9. Departments of Epidemiology, Prevention and Screening, Alberta Cancer Board, Calgary, Alberta, Canada

    P M A Brasher

  10. 1776 St Clair Suite 401, St Paul, Minnesota, Canada

    M Rose

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  1. B J Donnelly
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Correspondence to B Weber.

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Donnelly, B., Saliken, J., Ernst, D. et al. Role of transrectal ultrasound guided salvage cryosurgery for recurrent prostate carcinoma after radiotherapy. Prostate Cancer Prostatic Dis 8, 235–242 (2005). https://doi.org/10.1038/sj.pcan.4500811

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  • DOI: https://doi.org/10.1038/sj.pcan.4500811

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