Abstract
In light of the growing interest in the concept of ‘uroselectivity’ and in the increased worldwide use of alpha-blockers for benign prostatic hyperplasia (BPH), this review evaluates the relative benefits of various alpha-blocking agents in the treatment of BPH. The pharmacological and physiological selectivity as well as the clinical efficacy and safety of alfuzosin, doxazosin (Cardura®), tamsulosin (Flomax®), and terazosin (Hytrin®) are compared. In reviewing efficacy and safety, emphasis is given to 17 placebo-controlled, double-blind trials of these alpha-blockers published in peer-reviewed journals. This review also considers long-term data, effects on blood pressure, costs, and dose ranges.
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Lowe, F. Alpha–1–adrenoceptor blockade in the treatment of benign prostatic hyperplasia. Prostate Cancer Prostatic Dis 2, 110–119 (1999). https://doi.org/10.1038/sj.pcan.4500302
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DOI: https://doi.org/10.1038/sj.pcan.4500302