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Cancer

Survival pathways meet their end

Conventional chemotherapeutic approaches to treating tumours can be hit-and-miss. One way to ensure successful treatment may be to go for the jugular of cancer-cell survival signalling as well.

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Figure 1: The complexity of survival through Akt signalling.

References

  1. Wendel, H. -G. et al. Nature 428, 332–337 (2004).

    Article  ADS  CAS  Google Scholar 

  2. Vivanco, I. & Sawyers, C. L. Nature Rev. Cancer 2, 489–501 (2002).

    Article  CAS  Google Scholar 

  3. Basu, S., Totty, N. F., Irwin, M. S., Sudol, M. & Downward, J. Mol. Cell 11, 11–23 (2003).

    Article  CAS  Google Scholar 

  4. Manning, B. D. & Cantley, L. C. Trends Biochem. Sci. 28, 573–576 (2003).

    Article  CAS  Google Scholar 

  5. Neshat, M. S. et al. Proc. Natl Acad. Sci. USA 98, 10314–10319 (2001).

    Article  ADS  CAS  Google Scholar 

  6. Lin, T. A. et al. Science 266, 653–656 (1994).

    Article  ADS  CAS  Google Scholar 

  7. Pause, A. et al. Nature 371, 762–767 (1994).

    Article  ADS  CAS  Google Scholar 

  8. Li, S. et al. J. Biol. Chem. 278, 3015–3022 (2003).

    Article  CAS  Google Scholar 

  9. Topisirovic, I. et al. Mol. Cell. Biol. 23, 8992–9002 (2003).

    Article  CAS  Google Scholar 

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McCormick, F. Survival pathways meet their end. Nature 428, 267–269 (2004). https://doi.org/10.1038/428267a

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