Studies of the retinoblastoma gene can still deliver surprises, and enlightenment. Several of the abnormalities in mice lacking this gene are, it seems, the indirect consequence of a placental defect.
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Dyson, N. A twist in a mouse tale. Nature 421, 903–904 (2003). https://doi.org/10.1038/421903a
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DOI: https://doi.org/10.1038/421903a