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Immunology

A block at the toll gate

Inflammatory immune responses are crucial to our body's well-being, but too strong a response can be harmful. A protein that keeps inflammation under control has now been discovered.

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Figure 1: Inflammatory responses.

References

  1. Akira, S., Takeda, K. & Kaisho, T. Nature Immunol. 2, 675–680 (2001).

    Article  CAS  Google Scholar 

  2. Kobayashi, K. et al. Cell 110, 191–202 (2002).

    Article  CAS  Google Scholar 

  3. Kanakaraj, P. et al. J. Exp. Med. 187, 2073–2079 (1998).

    Article  CAS  Google Scholar 

  4. Thomas, J. A. et al. J. Immunol. 163, 978–984 (1999).

    CAS  PubMed  Google Scholar 

  5. Suzuki, N. et al. Nature 416, 750–756 (2002).

    Article  ADS  CAS  Google Scholar 

  6. O'Neill, L. A. Trends Immunol. 23, 296–300 (2002).

    Article  CAS  Google Scholar 

  7. Nomura, F. et al. J. Immunol. 164, 3476–3479 (2000).

    Article  CAS  Google Scholar 

  8. Jacinto, R., Hartung, T., McCall, C. & Li, L. J. Immunol. 168, 6136–6141 (2002).

    Article  CAS  Google Scholar 

  9. Wesche, H. et al. J. Biol. Chem. 274, 19403–19410 (1999).

    Article  CAS  Google Scholar 

  10. Li, S., Strelow, A., Fontana, E. J. & Wesche, H. Proc. Natl Acad. Sci. USA 99, 5567–5572 (2002).

    Article  ADS  CAS  Google Scholar 

Download references

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Correspondence to Tak W. Mak or Wen-Chen Yeh.

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Mak, T., Yeh, WC. A block at the toll gate. Nature 418, 835–836 (2002). https://doi.org/10.1038/418835a

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