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HIV

A tough viral nut to crack

Nature volume 418, pages 594–595 (2002)Cite this article

HIV cannot multiply in certain human cells unless it expresses a protein called Vif, the function of which has finally been revealed. It seems that it overcomes a human protein that would otherwise block viral replication.

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Figure 1: How HIV-1 can overcome our cells' defences.

References

  1. Fisher, A. G. et al. Science 237, 888–893 (1987).

    Article  CAS  PubMed  Google Scholar 

  2. Strebel, K. et al. Nature 328, 728–773 (1987).

    Article  CAS  PubMed  Google Scholar 

  3. Sheehy, A. M., Gaddis, N. C., Choi, J. D. & Malim, M. H. Nature 418, 646–650 (2002); advance online publication, 14 July 2002 (doi:10.1038/nature00939).

    Article  CAS  PubMed  Google Scholar 

  4. von Schwedler, U., Song, J., Aiken, C. & Trono, D. J. Virol. 67, 4945–4955 (1993).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Gabuzda, D. H. et al. J. Virol. 66, 6489–6495 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Goncalves, J., Korin, Y., Zack, J. & Gabuzda, D. J. Virol. 70, 8701–8709 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Dornadula, G., Yang, S., Pomerantz, R. J. & Zhang, H. J. Virol. 74, 2594–2602 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Zhang, H., Pomerantz, R. J., Dornadula, G. & Sun, Y. J. Virol. 74, 8252–8261 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Khan, M. A. et al. J. Virol. 75, 7252–7265 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Dettenhofer, M., Cen, S., Carlson, B. A., Kleinum, L. & Yu, X.-F J. Virol. 74, 8938–8945 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Madani, N. & Kabat, D. J. Virol. 72, 10251–10255 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Simon, J. H. M., Gaddis, N. C., Fouchier, R. A. M. & Malim, M. H. Nature Med. 4, 1397–1400 (1998).

    Article  CAS  PubMed  Google Scholar 

  13. Pryciak, P. M. & Varmus, H. E. J. Virol. 66, 5959–5966 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Bhattacharya, S., Navaratnam, N., Morrison, J. R., Scott, J. & Taylor, W. R. Trends Biochem. Sci. 19, 105–106 (1994).

    Article  CAS  PubMed  Google Scholar 

  15. Novina, C. D. et al. Nature Med. 8, 681–686 (2002).

    Article  CAS  PubMed  Google Scholar 

  16. Jacque, J.-M, Triques, K. & Stevenson, M. Nature 418, 435–438 (2002); advance online publication, 26 June 2002 (doi:10.1038/nature00896).

    Article  CAS  PubMed  Google Scholar 

  17. Pomerantz, R. J. Nature Med. 8, 659–660 (2002).

    Article  CAS  PubMed  Google Scholar 

  18. Yang, S. C., Sun, Y. & Zhang, H. J. Biol. Chem. 276, 4889–4893 (2001).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Center for Human Virology, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, 19107, Pennsylvania, USA

    Roger J. Pomerantz

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  1. Roger J. Pomerantz
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Correspondence to Roger J. Pomerantz.

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Pomerantz, R. A tough viral nut to crack. Nature 418, 594–595 (2002). https://doi.org/10.1038/418594a

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