Nerve cells communicate by using chemical messengers, which are released from neurons after a 'priming' step. It seems that priming may be key to controlling the strength of chemical transmission.
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Dobrunz, L., Garner, C. Priming plasticity. Nature 415, 277–278 (2002). https://doi.org/10.1038/415277a
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DOI: https://doi.org/10.1038/415277a