Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Scientific Correspondence
  • Published:

22q11 deletion syndrome in childhood onset schizophrenia: an update

Molecular Psychiatry volume 9, pages 225–226 (2004)Cite this article

SIR – The 22q11 deletion syndrome (22q11DS) is a relatively common (population rate 0.01%)1 genetic anomaly associated with congenital physical defects and psychosis. To date, 22q11DS rates in adult onset schizophrenia (AOS) are reported as: two out of 100,1 one out of 300,3 one out of 329 cases of adult onset, and none among 141 cases of ‘juvenile onset’ (<18 years old, mean age=15.6) (Table 1).4 Thus, combined rate of 22q11DS in AOS samples is 4/870 (0.46%).

Table 1 Rates of 22q11 deletion syndrome in childhood onset schizophrenia and adult onset schizophrenia samples
Full size table

Childhood onset schizophrenia (COS) is a rare but severe form of the illness hypothesized to have high genetic loading. In COS, a high rate of several cytogenetic abnormalities including 22q11DS has been reported previously.5 Here, we provide an update on the rate and neurobiological characteristics of 22q11DS in COS and compare the rate with that in AOS.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Tezenas Du Montcel S, Mendizabai H, Ayme S, Levy A, Philip N . J Med Genet 1996; 33: 719.

  2. Karayiorgou M, Morris MA, Morrow B, Shprintzen RJ, Goldberg R, Borrow J et al. Proc Natl Acad Sci USA 1995; 92: 7612–7616.

  3. Arinami T, Ohtsuki T, Takase K, Shimizu H, Yoshikawa T, Horigome H et al. Schizophr Res 2001; 52: 167–170.

  4. Ivanov D, Kirov G, Norton N, Williams HJ, Williams NM, Nikolov I et al. Br J Psychiatry 2003; 183: 409–413.

    Article  CAS  Google Scholar 

  5. Nicolson R, Giedd JN, Lenane M, Hamburger S, Singaracharlu S, Bedwell J et al. Am J Psychiatry 1999; 156: 1575–1579.

  6. Schouten JP, McElgunn CJ, Waaijer R, Zwijnenburg D, Diepvens F, Pals G . Nucleic Acids Res 2002; 30: e57.

  7. Eliez S, Antonarakis SE, Morris MA, Dahoun SP, Reiss AL . Arch Gen Psychiatry 2001; 58: 64–68.

    Article  CAS  Google Scholar 

  8. Bassett AS, Chow EW, Weksberg R . Am J Med Genet 2000; 97: 45–51.

  9. Liu H, Abecasis GR, Heath SC, Knowles A, Demars S, Chen Y J . Proc Natl Acad Sci USA 2002; 99: 16859–16864.

Download references

Author information

Authors and Affiliations

  1. Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA

    A Sporn, A Addington, N Gogtay, D Greenstein, P Gochman, M Lenane, N Baker, J Tossell & J L Rapoport

  2. Department of Psychiatry, Stanford University School of Medicine, Stanford, CA, USA

    A L Reiss & J Hallmayer

  3. Laboratory of Genomic Diversity, NCI, Frederick, MD, USA

    M Dean & U Potocnik

Authors
  1. A Sporn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Addington
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A L Reiss
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M Dean
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N Gogtay
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. U Potocnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D Greenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J Hallmayer
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. P Gochman
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M Lenane
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. N Baker
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. J Tossell
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. J L Rapoport
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A Sporn.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sporn, A., Addington, A., Reiss, A. et al. 22q11 deletion syndrome in childhood onset schizophrenia: an update. Mol Psychiatry 9, 225–226 (2004). https://doi.org/10.1038/sj.mp.4001477

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.mp.4001477

This article is cited by

Search

Advanced search

Quick links