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Evidence for a putative bipolar disorder locus on 2p13–16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21–24, 13q32, 14q21 and 17q11–12

Molecular Psychiatry volume 8, pages 333–342 (2003)Cite this article

Abstract

Bipolar disorder (BP) is a severe and common psychiatric disorder characterized by extreme mood swings. Family, twin and adoption studies strongly support a genetic component. The mode of inheritance is complex and likely involves multiple, as yet unidentified genes. To identify susceptibility loci, we conducted a genome-wide scan with 343 microsatellite markers in one of the largest, well-characterized pedigree samples assembled to date (373 individuals in 40 pedigrees). To increase power to detect linkage, scan statistics were used to examine the logarithm of odds (lod) scores based on evidence at adjacent chromosomal loci. This analysis yielded significant evidence of linkage (genome-wide P<0.05) for markers on 2p13–16. Standard linkage analysis was also supportive of linkage to 2p13–16 (lod=3.20), and identified several other interesting regions: 4q31 (lod=3.16), 7q34 (lod=2.78), 8q13 (lod=2.06), 9q31 (lod=2.07), 10q24 (lod=2.79), 13q32 (lod=2.2), 14q21 (lod=2.36) and 17q11–12 (lod=2.75). In this systematic, large-scale study, we identified novel putative loci for BP (on 2p13–16, 8q13 and 14q21) and found support for previously proposed loci (on 4q31, 7q34, 9q31, 10q21–24, 13q32 and 17q11–12). Two of the regions implicated in our study, 2p13–14 and 13q32, have also been linked to schizophrenia, suggesting that the two disorders may have susceptibility genes in common.

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Acknowledgements

We thank the families for their cooperation and support. This work was supported by NIMH Grants MH42535 (MB), MH43979 (MB) and MH44292 (JO); NIMH Research Scientist Award MH00176 (MB); NARSAD-Windisch Young Investigator Award (JAK and J L), and by funds from the Columbia Genome Center and the New York State Office of Mental Health.

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Authors and Affiliations

  1. Columbia Genome Center, Columbia University, New York, NY, USA

    J Liu, S H Juo, A Grunn, X Tong, M Brito, N Park, G Penchaszadeh, T C Gilliam & M Baron

  2. Department of Psychiatry, Columbia University, New York, NY, USA

    J Liu, J E Loth, J Endicott, J A Knowles, T C Gilliam & M Baron

  3. Department of Epidemiology, Columbia University, New York, 10032, NY, USA

    S H Juo

  4. Department of Genetics and Development, Columbia University, New York, NY, USA

    T C Gilliam

  5. Laboratory of Statistical Genetics, The Rockefeller University, New York, NY, USA

    A Dewan & J Ott

  6. Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

    K Kanyas & B Lerer

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Liu, J., Juo, S., Dewan, A. et al. Evidence for a putative bipolar disorder locus on 2p13–16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21–24, 13q32, 14q21 and 17q11–12. Mol Psychiatry 8, 333–342 (2003). https://doi.org/10.1038/sj.mp.4001254

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