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Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic

Molecular Psychiatry volume 5, pages 350–356 (2000)Cite this article

Abstract

This review provides both a biological and clinical perspective on Time-Dependent Sensitization (TDS), an ancient amplified memory response to threat manifest in the ability of both drugs and nondrug stressors to induce neuronal and behavioral effects which strengthen entirely as a function of the passage of time following even a single or acute exposure. Evidence is presented to show that TDS may be involved in the development of a spectrum of diseases and how drug regimens based on the principles of TDS could provide a novel and revolutionary means of treating psychiatric and other illnesses.

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  1. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, 15213, PA, USA

    S M Antelman, J Levine & S Gershon

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  1. S M Antelman
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  2. J Levine
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  3. S Gershon
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Correspondence to S M Antelman.

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Antelman, S., Levine, J. & Gershon, S. Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic. Mol Psychiatry 5, 350–356 (2000). https://doi.org/10.1038/sj.mp.4000721

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