Abstract
We analyzed a deletion/insertion polymorphism within the promoter region of the serotonin transporter gene (5-HTTPLR) in 81 patients with late onset Alzheimer's (AD) disease (mean age 70.02 ± 8.13 years). Control groups included 81 normal subjects with comparable age (mean age 75.6 ± 10.2) and 82 younger normal subjects (mean age 37.4 ± 9.1). Statistical analysis showed a significant difference in the genotype and gene frequencies between the AD group and normal controls (χ2 = 9.021; 2 d.f. and χ2 = 5.59, 1 d.f., respectively, P<0.05) due to the higher frequency of the l allele and the lower frequency of the s allele in controls than among ad patients. however, no differences were found in the genotype frequencies in older as compared to younger normal control groups (χ2 = 0.337, 2 d.f. and P>0.05). The present study confirms, in a different population, that the short variant of the 5-HTTPLR polymorphism may be a risk factor for late onset AD.
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Oliveira, J., Gallindo, R., Maia, L. et al. The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease. Mol Psychiatry 3, 438–441 (1998). https://doi.org/10.1038/sj.mp.4000417
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DOI: https://doi.org/10.1038/sj.mp.4000417
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