Abstract
Endocytosis of antigen by antigen-presenting cells results in the production of peptides that bind to newly synthesized class II molecules of the major histocompatibility complex. A new population of class II-enriched vesicles has been discovered in B lymphocytes that accumulate internalized antigen but are distinct from endosomes and lysosomes. These vesicles also transiently accumulate newly synthesized class II and class II-peptide complexes and appear to be a compartment specialized for the transport and loading of class II molecules.
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References
Roche, P. A., Marks, M. S. & Cresswell, P. Nature 354, 392–394 (1991).
Germain, R. N. & Margoulies, D. H. A. Rev. Immun. 11, 403–450 (1993).
Hunt, D. F. et al. Science 256, 1817–1820 (1992).
Chicz, R. M. et al. J. exp. Med. 178, 27–47 (1993).
Rudensky, A., Preston, H. P., Hong, S. C., Barlow, A. & Janeway, C. J. Nature 353, 622–627 (1991).
Davidson, H. W., Reid, P. A., Lanzavecchia, A. & Watts, C. Cell 67, 105–116 (1991).
Neefjes, J. J., Stollorz, V., Peters, P. J., Geuze, H. J. & Ploegh, H. L. Cell 61, 171–183 (1990).
Neefjes, J. J. & Ploegh, H. L. EMBO J. 11, 411–416 (1992).
Lotteau, V. et al. Nature 348, 600–605 (1990).
Blake, O. & Dobberstein, B. Cell 63, 707–716 (1990).
Peters, P. J., Neefjes, J. J., Oorschot, V., Ploegh, H. L. & Geuze, H. J. Nature 349, 669–676 (1991).
Roche, P. A. & Cresswell, P. Proc. natn. Acad. Sci. USA 88, 3150–3154 (1991).
Teyton, L. et al. Nature 348, 39–44 (1990).
Guagliardi, L. E. et al. Nature 343, 133–139 (1990).
Harding, C. V., Unanue, E. R., Slot, J. W., Schwartz, A. L. & Geuze, H. J. Proc. natn. Acad. Sci. U.S.A. 87, 5553–5557 (1990).
Harding, C. V., Collins, D. S., Slot, J. W., Geuze, H. J. & Unanue, E. R. Cell 64, 393–401 (1991).
Lanzavecchia, A. Nature 314, 537–539 (1985).
Lanzavecchia, A. A. Rev. Immun. 8, 773–793 (1990).
Schmid, S. L., Fuchs, R., Male, P. & Mellman, I. Cell 52, 73–83 (1988).
Jensen, P. E. J. exp. Med. 174, 1111–1120 (1991).
Marsh, M. et al. J. Cell Biol. 104, 875–886 (1987).
Amigorena, S. et al. Science 256, 1808–1812 (1992).
Germain, R. N. & Hendrix, L. H. Nature 353, 134–139 (1991).
Fuchs, R., Male, P. & Mellman, I. J. biol. Chem. 264, 2212–2220 (1989).
van der Sluijs, P. et al. Proc. natn. Acad. Sci. U.S.A. 88, 6313–6317 (1991).
Harter, C. & Mellman, I. J. Cell Biol. 117, 311–325 (1992).
Sadegh, N. S. & Germain, R. N. Nature 353, 167–170 (1991).
Kelly, R. B. Nature 364, 487–488 (1993).
Matter, K., Whitney, J. A., Yamamoto, E. M. & Mellman, I. Cell 74, 1053–1064 (1993).
Loss, G. E. Jr, & Sant, A. J. J. Immun. 150, 3187–3197 (1993).
Bauerfeind, R., Regnier, V. A., Flatmark, T. & Huttner, W. B. Neuron 11, 105–121 (1993).
Cresswell, P. Proc. natn. Acad. Sci. U.S.A. 82, 8188–8192 (1985).
Schmid, S., Fuchs, R., Kielian, M., Helenius, A. & Mellman, I. J. Cell Biol. 108, 1291–1300 (1989).
van der Sluijs, P., Hull, M., Webster, P., Goud, B. & Mellman, I. Cell 70, 729–740 (1992).
Braunstein, N. S., Germain, R. N., Loney, K. & Berkowitz, N. J. Immun. 145, 1635–1645 (1990).
Rodriguez-Boulan, E. et al. Meth. Cell Biol. 32, 37–56 (1989).
Matter, K., Hunziker, W. & Mellman, I. Cell 71, 741–753 (1992).
Hanzel, D. et al. Sem. Cell Biol. 2, 341–353 (1992).
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Amigorena, S., Drake, J., Webster, P. et al. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes. Nature 369, 113–120 (1994). https://doi.org/10.1038/369113a0
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DOI: https://doi.org/10.1038/369113a0
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