Abstract
THE Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and bithorax (bx-C) complexes, and hence for the maintenance of segmental determination1–3. We report the predicted protein sequence of the Pc-G gene Posterior Sex Combs (Psc), and of the neighbouring and related gene Suppressor two of zeste (Su(z)2). Both genes encode large proteins that contain a 200 amino-acid domain identical over 37.4% that is also conserved in the murine oncogene bmi-1 (refs 4,5). At the amino terminus of this domain is a cysteine-rich sequence that has been proposed as a novel type of zinc finger6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Struhl, G. & Akam, M. EMBO J. 4, 3259–3264 (1985).
Wedeen, C., Harding, K. & Levine, M. Cell 44, 739–748 (1986).
Paro, R. Trends Genet. 5, 131–135 (1990).
van Lohuizen, M. et al. Cell 65, 737–752 (1991).
Haupt, Y., Alexander, W. S., Barri, G., Klinken, S. P. & Adams, J. M. Cell 65, 753–763 (1991).
Freemont, P. S., Hanson, I. M. & Trowsdale, J. Cell 64, 483–484 (1991).
Jurgens, G. Nature 316, 153–155 (1985).
Adler, P. N., Martin, E. C., Charlton, J. C. & Jones, K. Devl Genet. (in the press).
Wu, C.t., Jones, R. S., Lasko, P. F. & Gelbart, W. M. Molec. Gen. Genet. 218, 559–564 (1989).
Brunk, B. P. & Adler, P. N. Genetics 124, 145–156 (1990).
Brunk, B. P., Martin, E. C. & Adler, P. N. Genetics 128, 119–132 (1991).
Rogers, S., Wells, R. & Rechsteiner, M. Science 234, 364–369 (1986).
Chelsky, D., Ralph, R. & Jonak, G. Molec. cell. Biol. 6, 2487–2492 (1989).
Pearson, W. R. & Lipman, D. J. Proc. natn. Acad. Sci. U.S.A. 85, 2444–2448 (1988).
van Lohuizen, M., Frasch, M., Wientjes, E. & Berns, A. Nature 353, 353–355 (1991).
Brunk, B. P. & Adler, P. N. Nucleic Acids Res. 19, 3149 (1991).
Brunk, B. P. thesis, Univ. Virginia (1989).
Everett, R. D. J. molec. Biol. 202, 87–96 (1988).
Jones, J. S., Weber, S. & Prakash, L. Nucleic Acids Res. 16, 7119–7131 (1988).
Schatz, D. G., Oettinger, M. A. & Baltimore, D. Cell 59, 1035–1048 (1989).
Patarca, R. et al. Proc. natn. Acad. Sci. U.S.A. 85, 2733–2737 (1988).
Itoh, K., Itoh, Y. & Frank, M. B. J. clin. Invest. 87, 177–186 (1991).
Smiley, B. L., Stadnyk, A. W., Myler, P. J. & Stuart, K. Molec. cell. Biol. 10, 6436–6444 (1990).
Davison, A. J. & Scott, J. E. J. gen. Virol. 67, 1759–1786 (1987).
Takahashi, M., Inaguma, Y., Hiai, H. & Hirose, F. Molec. cell. Biol. 8, 1853–1856 (1988).
Theim, S. & Miller, L. K. J. Virol. 63, 4489–4497 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Brunk, B., Martin, E. & Adler, P. Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene. Nature 353, 351–353 (1991). https://doi.org/10.1038/353351a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/353351a0
This article is cited by
-
H2AK121ub in Arabidopsis associates with a less accessible chromatin state at transcriptional regulation hotspots
Nature Communications (2021)
-
Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells
Scientific Reports (2017)
-
Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment
Journal of Hematology & Oncology (2016)
-
Polycomb group genes are required to maintain a binary fate choice in the Drosophila eye
Neural Development (2015)
-
BMI1–RING1B is an autoinhibited RING E3 ubiquitin ligase
Nature Communications (2015)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.