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Bcl-2 maintains B cell memory

Nature volume 353, pages 71–73 (1991)Cite this article

Abstract

THE number of lymphocytes in an animal is remarkably constant despite antigen-driven proliferation and a high rate of B-cell lymphopoiesis. This reflects the relatively brief lifespan of many newly generated B cells and argues for a well-regulated death mechanism1–3. Even so, a secondary immune response can be generated years after a primary exposure to antigen4. Antigen that might restimulate B cells persists for extended periods on follicular dendritic cells in the light zone of germinal centres5–13. Antigen-binding B cells have also been found months after the end of obvious cell division14. The precise signal that enables certain B cells to emerge as long-term surviving memory cells14–17 is unknown. Bcl-2, an inner mitochondrial membrane protein18, blocks programmed cell death in B cells18–20. We report here that this proto-oncogene maintains immune responsiveness. Transgenic mice overproducing Bcl-2 have a long-term persistence of immunoglobulin-secreting cells and an extended lifetime for memory B cells.

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References

  1. Opstelten, D. & Osmond, D. G. J. Immun. 131, 2635–2640 (1983).

    CAS  PubMed  Google Scholar 

  2. Gray, D. J. exp. Med. 167, 805–816 (1988).

    Article  CAS  Google Scholar 

  3. Forster, I. & Rajewsky, K. Proc. natn. Acad. Sci. U.S.A. 87, 4781–4784 (1990).

    Article  ADS  CAS  Google Scholar 

  4. Berek, C., Jarvis, J. M. & Milstein, C. Eur. J. Immun. 17, 1121–1129 (1987).

    Article  CAS  Google Scholar 

  5. Tew, T. G. & Mandel, T. E. Immunology 37, 69–77 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Klaus, G. G. B., Humphrey, J. G., Kunkle, A. & Dougworth, D. W. Immunol. Rev. 53, 3–28 (1980).

    Article  CAS  Google Scholar 

  7. Coico, R. F., Bhogel, B. S. & Thorbecke, G. J. J. Immun. 131, 2254–2257 (1983).

    CAS  PubMed  Google Scholar 

  8. Kraal, G., Weissman, I. L., Butcher, L. C. Cell. Immun. 115, 78–87 (1988).

    Article  CAS  Google Scholar 

  9. Kosko, M. H., Burton, G. F., Kapasi, Z. F., Szakal, A. K. & Tew, J. G. Immunology 68, 312–318 (1989).

    Google Scholar 

  10. Kraal, G., Weissman, I. L. & Butcher, E. C. Nature 298, 377–379 (1982).

    Article  ADS  CAS  Google Scholar 

  11. MacLennan, I. C. M. & Gray, D. Immunol. Rev. 91, 61–85 (1986).

    Article  CAS  Google Scholar 

  12. Liu, Y-J. et al. Nature 342, 929–931 (1989).

    Article  ADS  CAS  Google Scholar 

  13. Fliedner, T. M., Kesse, M., Cronkite, E. P. & Robertson, T. S. Ann. N. Y. Acad. Sci. 13, 578–594 (1964).

    ADS  Google Scholar 

  14. Schittek, B. & Rajewsky, K. Nature 346, 749–751 (1990).

    Article  ADS  CAS  Google Scholar 

  15. Gowans, J. L. & Uhr, J. W. J. exp. Med. 124, 1017–1030 (1966).

    Article  CAS  Google Scholar 

  16. Colle, J. H., Truffe-Bachi, P. & Freitas, A. Eur. J. Immun. 18, 1307–1314 (1988).

    Article  CAS  Google Scholar 

  17. Linton, P. J., Decker, D. J. & Klinman, N. R. Cell 59, 1049–1059 (1989).

    Article  Google Scholar 

  18. Hockenbery, D., Nun̄ez, G., Milliman, C., Schreiber, R. D. & Korsmeyer, S. J. Nature 348, 334–338 (1990).

    Article  ADS  CAS  Google Scholar 

  19. Vaux, D. L., Cory, S. & Adams, J. M. Nature 335, 440–442 (1988).

    Article  ADS  CAS  Google Scholar 

  20. Nunez, G. et al. J. Immun. 144, 3602–3610 (1990).

    CAS  PubMed  Google Scholar 

  21. McDonnell, T. J. et al. Cell 57, 79–88 (1989).

    Article  CAS  Google Scholar 

  22. McDonnell, T. J. et al. Molec. cell. Biol. 10, 1901–1907 (1990).

    Article  CAS  Google Scholar 

  23. Siekevitz, M., Kocks, C., Rajewsky, K. & Dildrop, R. Cell 48, 757–770 (1987).

    Article  CAS  Google Scholar 

  24. Celada, F. J. exp. Med. 125, 199–212 (1967).

    Article  CAS  Google Scholar 

  25. Gray, D. & Skarvall, H. Nature 336, 70–72 (1988).

    Article  ADS  CAS  Google Scholar 

  26. Pezella, F. et al. Am. J. Path. 137, 225–232 (1990).

    Google Scholar 

  27. Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M. & Korsmeyer, S. J. Proc. natn. Acad. Sci. U.S.A. (in the press).

  28. Graninger, W. G., Seto, M., Boutain, B., Goldman, P. & Korsmeyer, S. J. J. clin. Invest. 80, 1512–1515 (1987).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Howard Hughes Medical Institute and the Departments of Medicine, Molecular Microbiology and Pathology, Washington University School of Medicine, Saint Louis, Missouri, 63110, USA

    Gabriel Nuñez, David Hockenbery, Timothy J. McDonnell, Craig M. Sorensen & Stanley J. Korsmeyer

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  1. Gabriel Nuñez
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  2. David Hockenbery
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  3. Timothy J. McDonnell
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  4. Craig M. Sorensen
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  5. Stanley J. Korsmeyer
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Nuñez, G., Hockenbery, D., McDonnell, T. et al. Bcl-2 maintains B cell memory. Nature 353, 71–73 (1991). https://doi.org/10.1038/353071a0

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