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Commentary — reconsolidation

Strengthening the shaky trace through retrieval

Abstract

Retrieval of fear conditioning turns memory into a labile state sensitive to disruption. Here, I raise the issue that in addition to aversive, amygdala-dependent memories, other forms of memory are susceptible to the same effect, and I review evidence indicating that neuromodulation may have a significant influence on the reconsolidation process.

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Figure 1: Krechevsky maze.

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References

  1. McGaugh, J. L. Memory — a century of consolidation. Science 287, 248–251 (2000).

    Article  CAS  Google Scholar 

  2. Miller, R. R & Matzel, L. D. Memory involves far more than 'consolidation'. Nature Rev. Neurosci. 1, 214–216 (2000).[ Abstract]

    Article  CAS  Google Scholar 

  3. Nader, K., Schafe, G. E. & LeDoux, J. E. Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature 406, 722–726 (2000).

    Article  CAS  Google Scholar 

  4. Sara, S. J. Retrieval and reconsolidation: toward a neurobiology of remembering. Learn. Mem. 7, 73–84 ( 2000).

    Article  CAS  Google Scholar 

  5. Lewis, D., Bregman, N. J. & Mahan, J. Cue-dependent amnesia in rats. J. Comp. Physiol. Psychol. 81, 243–247 ( 1972).

    Article  CAS  Google Scholar 

  6. Lewis, D. J. & Bregman, N. J. Source of cues for cue-dependent amnesia in rats. J. Comp. Physiol. Psychol. 85, 421–426 (1973).

    Article  CAS  Google Scholar 

  7. Bregman, N. Nicholas, T. & Lewis, D. Cue-dependent amnesia: Permanence and memory return . Physiol. Behav. 17, 267– 270 (1976).

    Article  CAS  Google Scholar 

  8. Squire, L. R. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans Psychol. Rev. 99, 195– 231 (1992).

    Article  CAS  Google Scholar 

  9. Przybyslawski, J. & Sara, S. J. Reconsolidation of memory after its reactivation. Behav. Brain Res. 84, 241–246 (1997).

    Article  CAS  Google Scholar 

  10. Sara, S. J., Roullet, P. & Przybyslawski, J. Consolidation of memory for odor-reward association: β-adrenergic receptor involvement in the late phase. Learn. Mem. 6, 88–95 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Przybyslawski, J., Roullet, P. & Sara, S. J. Attenuation of emotional and nonemotional memories after their reactivation: role of β-adrenergic receptors. J. Neurosci. 19, 6623–6628 ( 1999).

    Article  CAS  Google Scholar 

  12. Roullet, P. & Sara, S. J. Consolidation of memory after its reactivation: involvement of β-noradrenergic receptors in the late phase . Neural Plast. 6, 63–68 (1998).

    Article  CAS  Google Scholar 

  13. Mayford, M., Abel, T. & Kandel, E. R. Transgenic approaches to cognition. Curr. Opin. Neurobiol. 5, 141–148 (1995).

    Article  CAS  Google Scholar 

  14. Devietti, T. L., Conger, G. L. & Kirkpatrick, B. R. Comparison of the enhancement gradients of retention obtained with stimulation of the mesencephalic reticular formation after training or memory reactivation. Physiol. Behav. 19, 549–554 (1977).

    Article  CAS  Google Scholar 

  15. Sara, S. J., Deweer, B. & Hars, B. Reticular stimulation facilitates retrieval of a 'forgotten' maze habit. Neurosci. Lett. 18, 211– 217 (1980).

    Article  CAS  Google Scholar 

  16. Dekeyne, A., Deweer, B. & Sara, S. J. Background stimuli as a reminder after spontaneous forgetting: Potentiation by stimulation of the mesencephalic reticular formation. Psychobiology 15, 161–166 (1987).

    Google Scholar 

  17. Devauges, V. & Sara, S. J. Memory retrieval enhancement by locus coeruleus stimulation: evidence for mediation by β-receptors. Behav. Brain Res. 43, 93–97 (1991).

    Article  CAS  Google Scholar 

  18. James, W. The Principles of Psychology (Henry Holt, New York, 1890).

    Google Scholar 

  19. Spear, N. E. & Mueller, C. W. in Memory Consolidation: Psychobiology of Cognition 111–147 (Lawrence Erlbaum Associates, Hillsdale, New Jersey, 1984).

    Google Scholar 

  20. Tulving, E. & Thomson, D. Encoding specificity and retrieval processes in episodic memory. Psychol. Rev. 80, 352–372 (1973).

    Article  Google Scholar 

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Sara, S. Strengthening the shaky trace through retrieval. Nat Rev Neurosci 1, 212–213 (2000). https://doi.org/10.1038/35044575

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