Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

Mitochondrial proteins essential for viability mediate protein import into yeast mitochondria

Nature volume 349, pages 205–208 (1991)Cite this article

Abstract

Only five mitochondrial proteins are known to be essential for viability of the yeast Saccharomyces cerevisiae; all of them are key components of the mitochondrial protein import system. Other components of this system are not essential for life; they include functionally redundant import receptors on the mitochondrial surface and enzymes acting upon only a few precursor proteins.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Tzagoloff, A. Mitochondria (Plenum, New York, 1982).

    Google Scholar 

  2. Criddle, R. S. & Schatz, G. Biochemistry 8, 322–334 (1969).

    Article  CAS  Google Scholar 

  3. Barret, J. in Biochemistry of Parasites and Host-Parasite Relationships (ed. Van den Bossche) 67–80 (Elsevier, Amsterdam, 1976).

    Google Scholar 

  4. Attardi, G. & Schatz, G. A. Rev. Cell Biol. 4, 289–333 (1988).

    Article  CAS  Google Scholar 

  5. Hartl, F.-U. & Neupert, W. Science 247, 930–938 (1990).

    Article  ADS  CAS  Google Scholar 

  6. Ellis, J. Nature 328, 378–379 (1987).

    Article  ADS  CAS  Google Scholar 

  7. Botstein, D. & Fink, G. R. Science 240, 1439–1443 (1988).

    Article  ADS  CAS  Google Scholar 

  8. Yaffe, M. P. & Schatz, G. Trends biochem. Sci. 9, 179–181 (1984).

    Article  Google Scholar 

  9. Yaffe, M. P. & Schatz, G. Proc. natn. Acad. Sci. USA 81, 4819–4823 (1984).

    Article  ADS  CAS  Google Scholar 

  10. Pollock, R. A. et al. EMBO J. 7, 3493–3500 (1988).

    Article  CAS  Google Scholar 

  11. Witte, C., Jensen, R. E., Yaffe, M. P. & Schatz, G. EMBO J. 7, 1439–1447 (1988).

    Article  CAS  Google Scholar 

  12. Jensen, R. E. & Yaffe, M. P. EMBO J. 7, 3863–3871 (1988).

    Article  CAS  Google Scholar 

  13. Yang, M., Jensen, R. E., Yaffe, M. P. & Schatz, G. EMBO J. 7, 3857–3862 (1988).

    Article  CAS  Google Scholar 

  14. Boehni, P. C., Gasser, S., Leaver, C. & Schatz, G. in The Organization and Expression of the Mitochondrial Genome (eds Kroon, A. M. & Saccone, C.) 423–433 (Elsevier, Amsterdam, 1980).

    Google Scholar 

  15. McAda, P. & Douglas, M. G. J. biol. Chem. 257, 3177–3182 (1982).

    CAS  PubMed  Google Scholar 

  16. Hawlitschek, G. et al. Cell 53, 759–806 (1988).

    Article  Google Scholar 

  17. Geli, V., Yang, M., Suda, K., Lustig, A. & Schatz, G. J. biol. Chem. 265, 19216–19222 (1990).

    CAS  PubMed  Google Scholar 

  18. Schneider, H., Arretz, M., Wachter, E. & Neupert, W. J. biol. Chem. 265, 9881–9887 (1990).

    CAS  PubMed  Google Scholar 

  19. Yang, M. et al. J. biol. Chem. 266, in the press (1991).

  20. Roise, D. & Schatz, G. J. biol. Chem. 263, 4509–4511 (1988).

    CAS  PubMed  Google Scholar 

  21. Cheng, M. Y. et al. Nature 337, 620–625 (1989).

    Article  ADS  CAS  Google Scholar 

  22. McMullin, T. W. & Hallberg, R. L. Molec cell. Biol. 8, 371–380 (1988).

    Article  CAS  Google Scholar 

  23. Ostermann, J., Horwich, A. L., Neupert, W. & Hartl, F.-U. Nature 341, 125–130 (1989).

    Article  ADS  CAS  Google Scholar 

  24. Scherer, P., Kreig, U. C., Hwang, S. T., Vestweber, D. & Schatz, G. EMBO J. 9, 4315–4322 (1990).

    Article  CAS  Google Scholar 

  25. Kang, P.-J. et al. Nature 348, 137–142 (1990).

    Article  ADS  CAS  Google Scholar 

  26. Craig, E. A. et al. Molec. cell. Biol. 9, 3000–3008 (1989).

    Article  CAS  Google Scholar 

  27. Morishima, N., Nakagawa, K.-I., Yamamoto, E. & Shibata, T. J. biol. Chem. 265, 15189–15197 (1990).

    CAS  PubMed  Google Scholar 

  28. Deshaies, R. J., Koch, B. D., Wemer-Washburne, M., Craig, E. A. & Schekman, R. Nature 332, 800–804 (1988).

    Article  ADS  CAS  Google Scholar 

  29. Murakami, H., Pain, D. & Blobel, G. J. Cell Biol. 107, 2051–2058 (1988).

    Article  CAS  Google Scholar 

  30. Vestweber, D., Brunner, J., Baker, A. & Schatz, G. Nature 341, 205–209 (1988).

    Article  ADS  Google Scholar 

  31. Baker, K. P., Schaniel, A., Vestweber, D. & Schatz, G. Nature 348, 605–609 (1990).

    Article  ADS  CAS  Google Scholar 

  32. Kiebler, M. et al. Nature 348, 610–616 (1990).

    Article  ADS  CAS  Google Scholar 

  33. Pfaller, R., Steger, H. F., Rassow, J., Pfanner, N. & Neuport, W. J. Cell Biol. 107, 2483–2490 (1988).

    Article  CAS  Google Scholar 

  34. Riezman, H., Hay, R., Witte, C., Nelson, N. & Schatz, G. EMBO J. 2, 1112–1118 (1983).

    Google Scholar 

  35. Zwizinki, C., Schleyer, M. & Neupert, W. J. biol. Chem. 259, 7850–7856 (1984).

    Google Scholar 

  36. Ohba, M. & Schatz, G. EMBO J. 6, 2109–2115 (1987).

    Article  CAS  Google Scholar 

  37. Hase, T., Müller, U., Riezman, H. & Schatz, G. EMBO J. 3, 3157–3164 (1984).

    Article  CAS  Google Scholar 

  38. Hines, V. et al. EMBO J. 9, 3191–3200 (1990).

    Article  CAS  Google Scholar 

  39. Hase, T., Riezman, H., Suda, K. & Schatz, G. EMBO J. 2, 2169–2172 (1983).

    Article  CAS  Google Scholar 

  40. Boguski, M. S., Sikorski, R. S., Hieter, P. & Goebl, M. Nature 346, 114 (1990).

    Article  ADS  CAS  Google Scholar 

  41. Sikorski, R. S., Boguski, M. S., Goebl, M. & Hieter, P. Cell 60, 307–317 (1990).

    Article  CAS  Google Scholar 

  42. Söllner, T., Pfaller, R., Griffiths, G., Pfanner, N. & Neupert, W. Cell 62, 107–115 (1990).

    Article  Google Scholar 

  43. Pain, D., Murakami, H. & Blobel, G. Nature 347, 444–449 (1990).

    Article  ADS  CAS  Google Scholar 

  44. Murakami, H., Blobel, G. & Pain, D. Nature 347, 488–491 (1990).

    Article  ADS  CAS  Google Scholar 

  45. Ono, H. & Tuboi, S. J. Biochem. 107, 840–845 (1990).

    Article  CAS  Google Scholar 

  46. Söllner, T., Griffiths, G., Pfaller, R., Pfanner, N. & Neupert, W. Cell 59, 1061–1070 (1989).

    Article  Google Scholar 

  47. Nicholson, D. W., Hergersberg, C. & Neupert, W. J. Biol. Chem. 263, 19034–19042 (1988).

    CAS  PubMed  Google Scholar 

  48. Nicholson, D. W., Kohler, H. & Neupert, W. Eur. J. Biochem. 164, 147–157 (1987).

    Article  CAS  Google Scholar 

  49. Dumont, M. E., Ernst, J. F. & Sherman, F. J. biol. Chem. 263, 15928–15937 (1988).

    CAS  PubMed  Google Scholar 

  50. Nicholson, D. W., Stuart, R. A. & Neupert, W. J. biol. Chem. 264, 10156–10168 (1989).

    CAS  PubMed  Google Scholar 

  51. Pratje, E., Mannhaupt, G., Michealis, G. & Beyreuther, K. EMBO J. 2, 1049–1054 (1983).

    Article  CAS  Google Scholar 

  52. Pratje, E. & Guiard, B. EMBO J. 5, 1313–1317 (1985).

    Article  Google Scholar 

  53. Schneider, A. et al. EMBO J. 10 (in the press).

  54. Yaffe, M. P., Ohta, S. & Schatz, G. EMBO J. 4, 2069–2047 (1985).

    Article  CAS  Google Scholar 

  55. Kalousek, F., Hendrick, J. P. & Rosenberg, L. E. Proc. natn. Acad. Sci. U.S.A. 85, 7536–7540 (1988).

    Article  ADS  CAS  Google Scholar 

  56. Murakami, K. & Mori, M. EMBO J. 9, 3201–3208 (1990).

    Article  CAS  Google Scholar 

  57. Ou, W.-J., Ito, A., Okazaki, H. & Omura, T. EMBO J. 8, 2605–2612 (1990).

    Article  Google Scholar 

  58. Prasad, T. K., Hack, E. & Hallberg, R. L. Molec. cell. Biol. 10, 3979–3986 (1990).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biocentre of the University of Basel, CH-4056, Basel, Switzerland

    Kevin P. Baker & Gottfried Schatz

Authors
  1. Kevin P. Baker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gottfried Schatz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baker, K., Schatz, G. Mitochondrial proteins essential for viability mediate protein import into yeast mitochondria. Nature 349, 205–208 (1991). https://doi.org/10.1038/349205a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/349205a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing