Abstract
ASSOCIATIVE stimulation of N-methyl-D-aspartate (NMDA) receptors and quisqualate ionotropic receptors (Qj) induces long-term potentiation at particular glutamatergic synapses1–7. Release of arachidonic acid as a result of stimulation of NMDA receptors8has been proposed to play a part in the establishment of long-term potentiation9–11. But long-term plasticity events at some other glutamatergic synapses do not involve activation of NMDA receptors11–15. Here we report that in mature striatal neurons in primary cultures, quisqualate can release arachidonic acid by associatively activating both quisqualate metabotropic receptors coupled to phospholipase C (Qp) (refs 16–20) and Qi receptors21. Independent activation of these two receptor types with specific agonists did not stimulate arachidonic acid release. These results support a role for the associative activation of Qp and Qf receptors in synaptic plasticity events12–14, including long-term potentiation at par-ticular synapses11,15.
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Dumuis, A., Pin, J., Oomagari, K. et al. Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors. Nature 347, 182–184 (1990). https://doi.org/10.1038/347182a0
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DOI: https://doi.org/10.1038/347182a0
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