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Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

Nature volume 344, pages 309–313 (1990)Cite this article

Abstract

Transgenic mice containing a human fetal (γ-) or adult (β-) globin gene linked to the β-globin gene locus activation region (LAR) express the gene throughout development. By contrast transgenic mice containing LAR linked to both a fetal and an adult globin gene display the normal developmental switch from fetal to adult gene expression. This suggests that the human fetal-to-adult globin gene switch is controlled through a mutually exclusive interaction between LAR and either the γ- or β-globin gene, resulting in the expression of only one gene at any given moment.

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Author information

Authors and Affiliations

  1. Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington, 98195, USA

    Tariq Enver, Natacha Raich, Allen J. Ebens & George Stamatoyannopoulos

  2. Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington, 98195, USA

    Thalia Papayannopoulou

  3. Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York, 10032, USA

    Frank Costantini

Authors
  1. Tariq Enver
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  2. Natacha Raich
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  3. Allen J. Ebens
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  4. Thalia Papayannopoulou
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  5. Frank Costantini
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  6. George Stamatoyannopoulos
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Enver, T., Raich, N., Ebens, A. et al. Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice. Nature 344, 309–313 (1990). https://doi.org/10.1038/344309a0

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