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Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

Nature volume 343, pages 133–139 (1990)Cite this article

Abstract

The pathways of intracellular traffic involved in antigen processing and presentation have been defined by immunoelectron microscopy. The export pathway for class II histocompatibility molecules and the antigen import pathway meet in a peripheral endocytic compartment having all the molecular machinery believed to be required for antigen processing and presentation, including internalized surface immunoglobulins, proteolytic enzymes and invariant chains. This compartment defines a site where peptides from endocytosed antigen can bind class II molecules en route to the cell surface for presentation to T cells.

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Authors and Affiliations

  1. Department of Pharmacy, School of Pharmacy, University of California, San Francisco, California, 94143, USA

    Lynne E. Guagliardi, Bruce Koppelman & Frances M. Brodsky

  2. Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, 63110, USA

    Janice S. Blum

  3. Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina, 27710, USA

    Michael S. Marks & Peter Cresswell

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Guagliardi, L., Koppelman, B., Blum, J. et al. Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. Nature 343, 133–139 (1990). https://doi.org/10.1038/343133a0

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