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Engineering monoclonal antibodies

Efforts to alter the mAb component of pharmaceuticals have focused on making them more human-lIke and smaller. Ultimately, the smallest molecular recognition unit derived from antibodies may be a single complementarity region.

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References

  1. Morrison, S.L., Johnson, M.J., Herzenberg, L.A. & Oi, V.T. Proc. natn. Acad. Sci. USA 81, 6851–6855 (1984).

    Article  ADS  CAS  Google Scholar 

  2. LoBuglio, A.F. et al. Proc. natn. Acad. Sci. USA 86, 4220–4224 (1989).

    Article  ADS  CAS  Google Scholar 

  3. Jones, P.T., Dear, P.H., Foote, J., Neuberger, M.S. & Winter, G. Nature 321, 522–525 (1986).

    Article  ADS  CAS  Google Scholar 

  4. Hale, G. et al. Lancet ii 8625, 1394–1399 (1988).

    Article  Google Scholar 

  5. Buchegger, F. et al. J exp. Med. 158, 413–427 (1983).

    Article  CAS  Google Scholar 

  6. Skerra, A. & Pluckthun, A. Science 240, 1038–1041 (1988).

    Article  ADS  CAS  Google Scholar 

  7. Riechmann, L. & Foote, J. J. molec. Biol. 203, 825–828 (1988).

    Article  CAS  Google Scholar 

  8. Huston, J.S. et al. Proc. natn. Acad. Sci. USA 85, 5879–5883 (1988).

    Article  ADS  CAS  Google Scholar 

  9. Bird, R.E. et al. Science 242, 423–426 (1988).

    Article  ADS  CAS  Google Scholar 

  10. Williams, W.V. et al. Proc. natn. Acad. Sci. USA 86, 5537–5541 (1989).

    Article  ADS  CAS  Google Scholar 

  11. Taub, R. et al. J. biol. Chem. 264, 259–265 (1989).

    CAS  PubMed  Google Scholar 

Download references

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Rodwell, J. Engineering monoclonal antibodies. Nature 342, 99–100 (1989). https://doi.org/10.1038/342099a0

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