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Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box

Abstract

The TATA sequence-binding factor TFIID plays a central role both in promoter activation by RNA polymerase II and other common initiation factors, and in promoter regulation by gene-specific factors. The sequence of yeast TFIID, which seems to be encoded by a single gene, contains interesting structural motifs that are possibly involved in these functions, and is similar to sequences of bacterial sigma factors.

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Horikoshi, M., Wang, C., Fujii, H. et al. Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box. Nature 341, 299–303 (1989). https://doi.org/10.1038/341299a0

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