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Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos

Nature volume 341, pages 33–38 (1989)Cite this article

Abstract

The expression of theXenopus homoeobox gene xhox3 is an early response to mesoderm induction by peptide growth factors and the level of xhox3 expression marks the antero-posterior character of the induced mesoderm. Different peptide growth factors specify different antero-posterior mesodermal cell fates as seen by the level of xhox3 expression and the capacity to induce specific secondary neural/epidermal structures. These factors and homoeobox genes thus form part of the mechanism necessary for establishing antero-posterior polarity in the frog embryo.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138, USA

    A. Ruiz i Altaba & D. A. Melton

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  1. A. Ruiz i Altaba
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  2. D. A. Melton
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i Altaba, A., Melton, D. Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos. Nature 341, 33–38 (1989). https://doi.org/10.1038/341033a0

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