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DNA sequence determinants of CAP-induced bending and protein binding affinity

Nature volume 333, pages 824–829 (1988)Cite this article

Abstract

The sites of DNA bending induced by binding catabolite activator protein are identified and shown to coincide with positions where DNA grooves face the protein. The bendability of DNA with different sequences at these bend centres parallels the bending preference of the sequences in nucleosomal DNA. Anisotropic DNA bendability significantly affects the structure and strength of regulatory protein –DNA complexes.

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Authors and Affiliations

  1. Department of Chemistry, Yale University, New Haven, Connecticut, 06511, USA

    Marc R. Gartenberg & Donald M. Crothers

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  1. Marc R. Gartenberg
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  2. Donald M. Crothers
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Gartenberg, M., Crothers, D. DNA sequence determinants of CAP-induced bending and protein binding affinity. Nature 333, 824–829 (1988). https://doi.org/10.1038/333824a0

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