Abstract
Generation of an immune response depends on the interaction of haematopoietic cell types, among which T cells and their receptors are of central importance. The T-cell receptor is a heterodimer consisting of disulphide-linked α andβ -chains, each chain divided into variable (V) and constant (C) regions1–4. Theβ -chain is encoded by the rearrangement of separate variable ( Vβ diversity (Dβ) and joining (Jβ) gene segments during T-cell differenti- ment and evolution of the β-gene segments, we have constructed a physical map of the human T-cell receptor β -chain family containing 40 Vβ gene segments as well as both Cβp gene clusters. A comparison of the published nucleotide sequences of human and murine Vβ gene segments reveals 12 examples of gene segments sharing 65% or more interspecies homology. The relative order of these human and murine Vβ gene segment homologues is also conserved along the chromosome, apart from more extensive human gene duplication, presumably as a consequence of con-straints imposed on evolutionary mechanisms operating to diversify these gene families or of selective pressures operating to maintain order.
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Lai, E., Concannon, P. & Hood, L. Conserved organization of the human and murine T-cell receptor β-gene families. Nature 331, 543–546 (1988). https://doi.org/10.1038/331543a0
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DOI: https://doi.org/10.1038/331543a0
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