Abstract
Cells which can suppress the immune response to an antigen (TS cells) appear to be essential for regulation of the immune system1,2. But the characterization of the TS lineage has not been extensive and many are sceptical of studies using uncloned or hybrid T-cell lines. The nature of the antigen receptor on these cells is unclear. T cells of the helper or cytotoxic lineages appear to recognize their targets using the T-cell receptor (TCR) αβ–CD3 complex3–5. TCR β-gene rearrangements are also found in some murine and human suppressor cell lines6–10 but others have been shown not to rearrange or express the β-chain11–13 or α-chain14 genes. We previously established TS clones derived from lepromatous leprosy patients15,16 which carry the CD8 antigen and recognize antigen in the context of the major histocompatibility complex (MHC) class II molecules in vitro16. We here report the characterization of additional MHC-restricted TS clones which rearrange TCR β genes, express messenger RNA for the α and β chains of the TCR and express clonally unique CD3-associated TCR αβ structures on their cell surface but do not express the γ chain of the γδ TCR on the cell surface. We conclude that antigen recognition by at least some human CD8+ suppressor cells is likely to be mediated by TCR αβ heterodimers.
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Green, D. R., Flood, R. M. & Gershon, R. K. A Rev. Immun. 11, 439–464 (1983).
Dorf, M. E. & Benacerraf, B. A Rev. Immun. 2, 127–158 (1984).
Yague, J. et al. Cell 42, 81–87 (1985).
Dembic, Z. et al. Nature 320, 232–238 (1986).
Saito, T., Weiss, A., Miller, J., Norcross, M. A. & Germain, R. N. Nature 325, 125–130 (1987).
Yoshikai, Y., Yanagi, Y., Suciu-Foca, N. & Msk, T. W. Nature 310, 506–508 (1984).
Royer, H. D., Bensussan, A., Acuto, O. & Rheinerz, E. L. J. exp. Med. 160, 947–952 (1984).
Toyonaga, B., Yanagi, Y., Suciu-Foca, N., Minden, M. & Mak, T. W. Nature 311, 385–2387 (1984).
Ballinari, D. et al. Eur. J. Immun. 15, 855–860 (1985).
De Santis, R. et al. Proc. natn. Acad. Sci. U.S.A. 82, 8638–8642 (1985).
Hedrick, S. M. et al. Proc. natn. Acad. Sci. U.S.A. 82, 531–535 (1985).
Kronenberg, M. et al. Nature 313, 647–653 (1985).
Blanckmeister, C. A., Yamamoro, K., Davis, M. M. & Hammerling, G. J. J. exp. Med. 162, 751–863 (1985).
Mori, L. et al. EMBO J. 4, 2025–2030 (1985).
Modlin, R. L. et al. J. Immun. 137, 2831–2834 (1986).
Modlin, R. L. et al. Nature 322, 459–461 (1986).
Bloom, B. R. & Godal, T. Rev. infect. Dis. 5, 765–779 (1983).
Bloom, B. R. J. Immun. 137, i–x (1986).
Mehra, V., Mason, L. H., Fields, J. P. & Bloom, B. R. J. Immun. 123, 1813–1817 (1979).
Mehra, V., Convit, J., Rubinstein, A. & Bloom, B. R. J. Immun. 129, 1946–1951 (1982).
Nelson, E., Wong, L., Uyamura, K., Rea, T. H. & Modlin, R. L . Cell. Immun. 104, 99–104 (1987).
Oettgen, H. C., Kappler, J., Tax, W. J. M. & Terhorst, C. J. biol. Chem. 259, 12039–12048 (1984).
Spits, H. et al. J. Immun. 135, 1922–1928 (1985).
Brenner, M. B. et al. Nature 322, 145–149 (1986).
Brenner, M. B. et al. J. Immun. 138, 1502–1509 (1987).
Brenner, M. B. et al. Nature 325, 689–694 (1987).
De Vries, R. R. P., Ottenhoff, T. H. M., Li, S. & Young, R. A. Lepr. Rev. 57, suppl. 2, 113–121 (1986).
Borst, J., Prendville, M. A. & Terhorst, C. J. Immun. 128, 1560–1565 (1982).
Mauer, S. C. et al. J. exp. Med. 157, 705–719 (1983).
Reinherz, E. L. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4104–4108 (1983).
Weiss, A. & Stobo, J. D. J. exp. Med. 160, 1284–1299 (1984).
Brenner, M. B., Trowbridge, I. S. & Strominger, J. L. Cell 40, 183–190 (1985).
Raulet, D. H., Garman, R. D., Saito, H. & Tonegawa, S. Nature 314, 103–107 (1985).
Snodgrass, H. R., Dembic, Z., Steinmetz, M. & von Boehmer, H. Nature 315, 232–233 (1985).
Dialynas, D. P. et al. Proc. natn. Acad. Sci. U.S.A. 83, 2619–2623 (1986).
Quertermous, T. et al. Nature 322, 184–187 (1986).
Rupp, F., Freeh, G., Hengartner, H., Zinkernagel, R. M. & Joho, R. Nature 321, 876–878 (1986).
Reilly, E. B., Kranz, D. M., Tonegawa, S. & Eisen, H. N. Nature 321, 878–880 (1986).
Murre, C. et al. Nature 316, 549–552 (1985).
Modlin, R. L. et al. J. Immun. 132, 3085–3090 (1984).
Ottenhof, T. H. M., Elferink, D. G., Klatser, P. R. & de Vries, R. R. P. Nature 322, 462–464 (1986).
Fox, E. J., Cook, R. G., Lewis, D. E. & Rich, R. R. J. clin. Invest. 78, 214–220 (1986).
Brenner, M. B., Trowbridge, I. S., McLean, J. & Strominger, J. L. J. exp. Med. 160, 541–551 (1984).
Samelson, L. E., Harford, J., Schwartz, R. H. & Klausner, R. D. Proc. natn. Acad. Sci. U.S.A. 82, 1969–1973 (1985).
Yelton, D. E., Desaymard, C. & Scharff, M. D. Hybridoma 1, 5–11 (1981).
Yanagi, Y. et al. Nature 308, 145–149 (1984).
Wigler, M. et al. Cell 16, 778–785 (1979).
Toyonaga, B., Yoshikai, Y., Vadasz, V., Chin, B. & Mak, T. W. Proc. natn. Acad. Sci. U.S.A. 82, 8624–8628 (1985).
Duby, A. D., Klein, K. A., Murre, C. & Seidman, J. G. Science 228, 1204–1206 (1985).
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Modlin, R., Brenner, M., Krangel, M. et al. T-cell receptors of human suppressor cells. Nature 329, 541–545 (1987). https://doi.org/10.1038/329541a0
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DOI: https://doi.org/10.1038/329541a0
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