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The Drosophila clock gene per affects intercellular junctional communication

Nature volume 328, pages 686–691 (1987)Cite this article

A Correction to this article was published on 10 December 1992

Abstract

The per locus of Drosophila has been implicated in the control of behavioural rhythms. In fruitfly embryos and larvae per is expressed in salivary glands. Per mutations have striking effects on intercellular communication in salivary glands: gap junction channels are modulated so that their conductance varies inversely with the period of behavioural rhythms in the mutants. A similar effect on junctional communication in the nervous system may explain how per influences behavioural rhythms.

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Author notes

  1. David C. Spray: Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA

  2. Michael W. Young: To whom reprint requests should be addressed.

Authors and Affiliations

  1. The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA

    Thaddeus A. Bargiello, Lino Saez, Mary K. Baylies, Gregory Gasic, Michael W. Young & David C. Spray

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  1. Thaddeus A. Bargiello
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  2. Lino Saez
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  3. Mary K. Baylies
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  4. Gregory Gasic
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  5. Michael W. Young
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  6. David C. Spray
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Bargiello, T., Saez, L., Baylies, M. et al. The Drosophila clock gene per affects intercellular junctional communication. Nature 328, 686–691 (1987). https://doi.org/10.1038/328686a0

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  • DOI: https://doi.org/10.1038/328686a0

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