Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

Nature volume 328, pages 38–43 (1987)Cite this article

Abstract

Biochemical and biophysical studies on Aplysia sensory neurons indicate that inhibitory responses to the molluscan peptide FMRFamide are mediated by lipoxygenase metabolites of arachidonic acid. These compounds are a new class of second messengers in neurons.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. 1. Rail, W. & Sutherland, R. J. / Am. chem. Soc. 79, 3608 (1957). 2. Siegelbaum, S. A. & Tsien, R. W. Trends Neurosci. 6, 307–313 (1983). 3. Kennedy, M. B. A. Rev. Neurosci. 6, 493–525 (1983). 4. Nestler, E..J. & Greengard, p. Nature 305, 583–588 (1983). 5. Paupardin–Tritsch, D., Hammohd, C., Gerschenfeld, H. M., Nairn, A. C. & Greengard, P. 29. Nature 323, 812–814 (1986). 6. Rasmussen, H. & Barrett, P. Physiol. Rev. 64, 938–984 (1984). 31. 7. De Riemer, S. A., Strong, J. A., Albert, K. A., Greengard, P. & Kaczmarek, L. Nature 313, 313–316 (1985). 8. Rane, S. G. & Dunlap, K. Proc. natn. Acad. ScL U.S.A. 83, 184–188 (1986). 9. Higashida, H. & Brown, D. A. Nature 323, 333–335 (1986). 10. Hammond, C., Paupardin–Tritsch, D., Nairn, A. C., Greengard, P. & Gerschenfeld, H. M. 35. Nature 325, 809–811 (1987). 11. Fisher, S. K. & Agranoff, B. W. J. Neurochem. 48, 909–1017 (1987). 12. Gilman, A. G. Cell 36, 577–579 (1984). 13. Pfaffinger, P., Martin, J., Hunter, D., Nathanson, N. & Hille, B. Nature 317, 536–538 (1985). 14. Breitweiser, G. & Szabo, G. Nature 317, 538–540 (1985). 15. Logothetis, D. E., Kurachi, Y., Galper, J., Neer, E. J. & Clapham, D. E. Nature 325, 321–326 41. (1987). . 16. Yatani, A., Codina, J., Brown, A. M. & Birnbaumer, L. Science 235, 207–211 (1987). 17. Needleman, P., Turk, J., Jakschick, B. A., Morrison, A. R. & Lefkowith, J. B. A. Rev. Biochem. 55, 69–102 {1986). 18. Samuelsson, E. Biochem. biophys. Acta 84, 218–219 (1964). 19. Sautebin, L., Spagnuolo, C., Galli, C. & Galli, G. Prostaglandins 16, 985–988 (1978). 20. Wolfe, L. S. J. Neurochem. 38, 1–14 (1982). 21. Lindgren, J. A., Hokfelt, T., Dahlen, S. E., Patrono, C. & Samuelsson, B. Proc. natn. Acad. Sci U.S.A. 81, 6212–6216 (1984). 22. Shimizu, T., Takusagawa, Y., Izumi, T., Ohishi, N. & Seyama, Y. / Neurochem. 48, 1541–1546 (1987). 23. Jelsema, C. L. & Axelrod, J. Proc. natn. Acad. Sci U.S.A. 84 (in the press). 24. Kandel, E. R. & Schwartz, J. H. Science 218, 433–443 (1982). 25. Klein, M., Camardo, J. S. & Kandel, E. R. Proc. natn. Acad, ScL US. A 79,5713–5717 (1982). 26. Siegelbaum, S. A., Camardo, J. S. & Kandel, E. R. Nature 299, 413–417 (1982). 27. Shuster, M. J:, Camardo, J. S., Siegelbaum, S. A. & Kandel, E. R. Nature 313,392–395 (1985). 28. Abrams, T. W., Castellucci, V. R, Camardo, J. S., Kandel, E. R. & Lloyd, P. E. Proc. natn. Acad. Sci. U.S.A. 81, 7956–7960 (1984). 29. Ocorr, K. A. & Byrne, J. H. Neurosci. Lett. 55, 113–118 (1985). 30. Brezina, V., Eckert, R. & Erxleben, C. /. Physiol., Lond. 382, 267–290 (1987). 31. Colombaioni, L., Paupardin–Tritsch, D., Vidal, P. P. & Gerschenfeld, H. M. J. Neurosci. 5, 2533–2538 (1985). 32. Ruben, P., Johnson, J. W. & Thompson, S. J. Neurosci. 6, 252–259 (1986). 33. Gottrell, G. A., Davies, N. W. & Green, K. A. /. Physiol, Lond. 356, 315–333 (1984). 34. Belardetti, R, Kandel, E. R. & Siegelbaum, S. A. Nature 325; 153–156 (1987). 35. Piomelli, D., Shapiro, E., Feinmark, S. J. & Schwartz, J. H. J. Neurosci (in the press). Kretz, R., Shapiro, E. & Kandel, E. R. J. Neurophysiol 55, 131–146 (1986). Choi, D. W. & Fischbach, G. D. / Neurophysiol. 45, 605–620 (1981). 38. Rayport, S. & Schacher, S. J. /. Neurosci. 6, 759–763 (1985). 39. Van den Bosch, H. Biochem. biophys. Acta 604, 191–246 (1980). 40. Irvine, R. R Biochem. J. 204, 3–16 (i982). 41. Flower, R. J. Br. med. Bull. 39, 260–264 (1983). 42. Shen, T. Y. & Winter, C. A. Adv. Drug. Res. 56, 665–675 (1977). 43. Egan, R. W. & Gale, P. H. in Prostaglandins, Leukotrienes and Lipoxins (ed. Bailey, J. M.) 593–607 (Plenum, New York, 1984), 44. Robison, G. A., Butcher, R. W. & Sutherland, E. W. Cyclic AMP (Academic, New York, 1971). 45. Kretz, R., Shapiro, E. & Kandel, E. R. /. Neurophysiol. 55, 113–130 (1986). 46. Dunlap, K. & Fischbach, G. D. Nature 276, 837–838 (1978). 47. Mudge, A., Leeman, S. & Fischbach, G. D. Proc. natn. Acad. Sci. U.S.A. 76, 526–530 (1979). 48. Hedqvist, P. A. Rev. Pharmac. Tax. 17, 259–279 (1977). 49. Wigstrom, H., Gustafson, B., Huang, Y–Y. & Abraham, W. D. Acta–physioL Scand. 126, 317–319 (1986). 50.Bliss, T. V. P., Douglas, R. M., Errington, M. C. & Lynch, M. A. /. Physiol., Lond. 377, 391–408 (1986).

Download references

Author information

Author notes

  1. F. Belardetti

    Present address: Department of Pharmacology, University of Texas, Health Science Center, Dallas, Texas, 75235, USA

Authors and Affiliations

  1. Howard Hughes Medical Institute and Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA

    N. Dale, S. A. Siegelbaum, E. R. Kandel, J. H. Schwartz & F. Belardetti

  2. Departments of Pharmacology, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA

    D. Piomelli, A. Volterra & S. A. Siegelbaum

  3. Departments of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA

    E. R. Kandel

  4. Departments of Physiology, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA

    J. H. Schwartz

  5. Departments of Neurology, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA

    J. H. Schwartz

Authors
  1. D. Piomelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Volterra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Dale
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. A. Siegelbaum
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. R. Kandel
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. H. Schwartz
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. F. Belardetti
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Piomelli, D., Volterra, A., Dale, N. et al. Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature 328, 38–43 (1987). https://doi.org/10.1038/328038a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/328038a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing