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Structure of the represser–operator complex of bacteriophage 434

Nature volume 326, pages 846–852 (1987)Cite this article

Abstract

The crystal structure of a specific complex between the DNA-binding domain of phage 434 represser and a synthetic 434 operator DNA shows interactions that determine sequence-dependent affinity. The represser recognizes its operators by its complementarity to a particular DNA conformation as well as by direct interaction with base pairs in the major groove.

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Author notes

  1. J. E. Anderson

    Present address: Cold Spring Harbor Laboratory, Cold Spring Harbor, Long Island, New York, 11724, USA

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts, 02138, USA

    J. E. Anderson, M. Ptashne & S. C. Harrison

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  1. J. E. Anderson
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  2. M. Ptashne
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  3. S. C. Harrison
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Anderson, J., Ptashne, M. & Harrison, S. Structure of the represser–operator complex of bacteriophage 434. Nature 326, 846–852 (1987). https://doi.org/10.1038/326846a0

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