Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Suppression of in vitro haematopoiesis following human immunodeficiency virus infection

Nature volume 326, pages 200–203 (1987)Cite this article

Abstract

Viral infections are frequently associated with haematological disorders (reviewed in ref. 1). Abnormalities including leukopenia, anaemia and thrombocytopenia are commonly observed in patients with the acquired immune deficiency syndrome (AIDS) or the AIDS-related complex (ARC)2–12. The underlying cause of these haematological abnormalities is poorly understood. We report here that bone marrow progenitors isolated from AIDS or ARC patients are responsive to recombinant human granulocyte-macrophage colony stimulating factor (rGM-CSF) and recombinant erythropoietin. Antibodies present in the serum of patients infected with the human immunodeficiency virus (HIV), however, could suppress the growth of these progenitors, but not the growth of progenitors from HIV seronegative controls. A component of this immune-mediated suppression appears to be antibodies directed towards the envelope glycoprotein (gp120) of HIV.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Young, N. & Mortimer, P. Blood 63, 729–737 (1984).

    Article  CAS  Google Scholar 

  2. Abrams, D. I. et al. Am. J. clin. Path. 81, 13–18 (1984).

    Article  CAS  Google Scholar 

  3. Spivak, J. L., Bender, B. S. & Quinn, T. C. Am. J. Med. 77, 224–228 (1984).

    Article  CAS  Google Scholar 

  4. Schneider, D. R. & Picker, L. J. Am. J. clin. Path. 84, 144–52 (1985).

    Article  CAS  Google Scholar 

  5. Castella, A., Croxson, T. S., Mildvan, D., Witt, D. H. & Zalunsky, R. Am. J. clin. Path. 84, 425–32 (1985).

    Article  CAS  Google Scholar 

  6. Geller, S. A., Muller, R., Greenberg, M. L. & Siegal, F. P. Archs Path. 109, 138–141 (1985).

    CAS  Google Scholar 

  7. Zon, L. I., Arkin, C. & Groopman, J. E. Br. J. Haemat. (in the press).

  8. Morris, L. et al. Ann. Intern. Med. 96, 714–717 (1982).

    Article  CAS  Google Scholar 

  9. Walsh, C., Nardi, M. & Karpatkin, S. New Engl. J. Med. 311, 635–639 (1984).

    Article  CAS  Google Scholar 

  10. Stricker, R. B., Abrams, D. I., Corash, L. & Shuman, M. A. N. Engl. J. Med. 313, 1375–1380 (1985).

    Article  CAS  Google Scholar 

  11. Murphy, M. F. et al. Lancet i, 217–218 (1985).

    Article  Google Scholar 

  12. Leiderman, I. Z., Greenberg, M. L., Adelsberg, B. R. & Siegal, F. P. in AIDS (eds Gottlieb, M. S. & Groopman, J. E.) 281–289 (Liss, New York, 1984).

    Google Scholar 

  13. Barre-Sinoussi, F. et al. Science 220, 868–871 (1983).

    Article  ADS  CAS  Google Scholar 

  14. Gallo, R. C. et al. Science 224, 500–503 (1984).

    Article  ADS  CAS  Google Scholar 

  15. Hammer, S. N., Gillis, J., Groopman, J. E. & Rose, R. M. Proc. natn. Acad. Sci. U.S.A. 83, 8734–8738 (1986).

    Article  ADS  CAS  Google Scholar 

  16. Busch, M., Beckstead, J., Gantz, D. & Vyas, G. Blood 68, 122a (1986).

    Google Scholar 

  17. Armstrong, J. A. & Horne, R. Lancet ii, 370–372 (1984).

    Article  Google Scholar 

  18. Gartner, S. et al. Science 233, 215–219 (1986).

    Article  ADS  CAS  Google Scholar 

  19. Gyorkey, F., Melnick, J. L., Sinkovics, J. G. & Gyorkey, P. Lancet i, 106 (1985).

    Article  Google Scholar 

  20. Koenig, S. et al. Science 233, 1089–1093 (1986).

    Article  ADS  CAS  Google Scholar 

  21. Salahuddin, S. Z., Rose, R. M., Groopman, J. E., Makham, P. D. & Gallo, R. C. Blood 68, 281–284 (1986).

    Article  CAS  Google Scholar 

  22. Ho, D. D. Rota, T. R. & Hirsch, M. S. J. clin. Invest. 77, 1712–1715 (1986).

    Article  CAS  Google Scholar 

  23. Gartner, S. et al. Science 233, 215–219 (1986).

    Article  ADS  CAS  Google Scholar 

  24. Levy, J. A. et al. Virology 147, 441–448 (1985).

    Article  CAS  Google Scholar 

  25. Nicholson, J. K. A., Cross, G. D., Callaway, C. S. & McDougal, J. S. J. Immun. 137, 323–329 (1986).

    CAS  PubMed  Google Scholar 

  26. Cortes, E., Koeffler, H. P., Gaynor, R. & Mitsuyasu, R. Blood 68, 123a (1986).

    Google Scholar 

  27. Lasky, L. A. et al. Science 233, 209–212 (1986).

    Article  ADS  CAS  Google Scholar 

  28. Metcalf, D. Int. J. Cancer 27, 577–584 (1981).

    Article  CAS  Google Scholar 

  29. Hall, B. M. Br. J. Haemat. 17, 553–561 (1969).

    Article  CAS  Google Scholar 

  30. Morley, A., Quesenberry, P., Bealmear, P., Stohlman, F. & Wilson, R. Proc. Soc. exp. Biol. Med. 140, 478–480 (1972).

    Article  CAS  Google Scholar 

  31. Murray, H. W., Rubin, B. Y., Masur, H. & Roberts, R. B. New Engl. J. Med. 310, 883–884 (1984).

    Article  CAS  Google Scholar 

  32. Cunningham Rundles, S., Michelis, M. A. & Masur, H. J. clin. Immun. 3, 156–165 (1983).

    Article  CAS  Google Scholar 

  33. Laurence, J., Gottlieb, A. B. & Kunkel, H. G. J. clin. Invest. 72, 2072–2081 (1983).

    Article  CAS  Google Scholar 

  34. Chervenick, P. A. & LoBuglio, A. F. Science 178, 164–166 (1972).

    Article  ADS  CAS  Google Scholar 

  35. Dinarello, C. A. Rev. infect. Dis. 6, 51–95 (1984).

    Article  CAS  Google Scholar 

  36. Zucali, J. R. et al. J. clin. Invest. 77, 1857–1863 (1986).

    Article  CAS  Google Scholar 

  37. Donahue, R. et al. Nature 321, 872–875 (1986).

    Article  ADS  CAS  Google Scholar 

  38. Wong, G. G. et al. Science 228, 810–815 (1985).

    Article  ADS  CAS  Google Scholar 

  39. Wong, G. G. et al. in Cancer Cells Vol. 3 (eds Feramisco, J., Ozanne, B. & Stiles, C.) 235–241 (Cold Spring Harbor Laboratory, New York, 1985).

    Google Scholar 

  40. Jacobs, K. et al. Nature 313, 806–810 (1985).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Genetics Institute Inc., 87 Cambridge Park Drive, Cambridge, Massachusetts, 02140, USA

    Robert E. Donahue & Steven C. Clark

  2. Division of Hematology/Oncology, Department of Medicine, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts, 02215, USA

    Margaret M. Johnson, Leonard I. Zon & Jerome E. Groopman

Authors
  1. Robert E. Donahue
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Margaret M. Johnson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Leonard I. Zon
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Steven C. Clark
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jerome E. Groopman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Donahue, R., Johnson, M., Zon, L. et al. Suppression of in vitro haematopoiesis following human immunodeficiency virus infection. Nature 326, 200–203 (1987). https://doi.org/10.1038/326200a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/326200a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing