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Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

Nature volume 313, pages 647–653 (1985)Cite this article

Abstract

Rearrangements of T-cell receptor β-chain genes are usually found on both chromosomal homologues, occurring by both deletional and non-deletional mechanisms. Two constant-region (Cβ) genes have been identified previously and at least one is transcribed in every helper or cytotoxic T cell tested, but the choice of Cβ gene expression is not correlated with the specialized functions of these T lymphocytes. By contrast, four of five suppressor T-cell hybridomas examined have deleted all known joining (Jβ) gene segments and Cβ genes and therefore may have antigen receptors encoded by different T-cell receptor gene families.

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Author notes

  1. Marie Malissen

    Present address: Centre d'Immunologie de Marseille-Luminy, Marseille, Cedex 9, France

Authors and Affiliations

  1. Division of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    Mitchell Kronenberg, Joan Goverman, Marie Malissen & Leroy Hood

  2. Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York, 10032, USA

    Regina Haars & Nicole Suciu-Foca

  3. Department of Cellular and Structural Biology, University of Texas Health Science Center, 7703 Floyd Curl Drive, University of Texas, San Antonio, Texas, 78284, USA

    Ellen Kraig

  4. Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, M5GIL6, Canada

    Laurie Phillips & Terry Delovitch

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Kronenberg, M., Goverman, J., Haars, R. et al. Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes. Nature 313, 647–653 (1985). https://doi.org/10.1038/313647a0

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