Abstract
The myc gene seems to have a causal role in tumour formation in man, mouse and avian systems1–3. The myc gene product has been localized to the nucleus4,5, suggesting that it may be involved in the regulation of gene expression. The level of expression of the mammalian heat shock protein 70 (HSP70) gene is elevated in several tumour cell lines6, implying that a cellular function expressed in these tumour lines can stimulate HSP70 production. We report here that the gene product of a rearranged mouse c-myc gene is capable of stimulating expression of chimaeric genes containing a Drosophila hsp70 promoter region and 5′-flanking sequences. This stimulation is dependent on sequences located more than 200 bases 5′ of the normal start of hsp70 transcription.
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References
Hayward, W. S., Neel, B. G. & Astrin, S. M. Nature 290, 475–479 (1981).
Shen-Ong, G. L. C., Keath, E. J., Piccoli, S. P. & Cole, M. D. Cell 31, 443–450 (1982).
Leder, P. et al. Science 222, 765–771 (1983).
Donner, P., Greiser-Wilke, I. & Moelling, K. Nature 296, 262–266 (1982).
Abrams, H. D., Rohrschneider, L. R. & Eisenman, R. N. Cell 29, 427–439 (1982).
Imperiale, M. J., Kao, H.-T., Feldman, L. T., Nevins, J. R. & Strickland, S. Molec. cell. Biol. 4, 867–874 (1984).
Land, H., Parada, L. F. & Weinberg, R. A. Nature 304, 596–601 (1983).
Holmgren, R., Livak, K., Morimoto, R., Freund, R. & Meselson, M. Cell 18, 1359–1370 (1979).
Karch, F., Torok, I. & Tissieres, A. J. molec. Biol. 148, 219–230 (1981).
Mason, P. J., Torok, I., Kiss, I., Karch, F. & Udvardy, A. J. molec. Biol. 156, 21–35 (1982).
Kaufman, R.J. & Sharp, P. A. Molec. cell. Biol. 2, 1304–1313 (1982).
Gorman, C. M., Moffat, L. F. & Howard, B. H. Molec. cell. Biol. 2, 1044–1051 (1982).
Di Nocera, P. P. & Dawid, I. B. Proc. natn. Acad. Sci. U.S.A. 80, 7095–7098 (1983).
Kingston, R. E., Kaufman, R. J. & Sharp, P. A. Molec. cell. Biol. 4, 1970–1977 (1984).
Urlaub, G. & Chasin, L. A. Proc. natn. Acad. Sci. U.S.A. 77, 4216–4220 (1980).
Urlaub, G., Kas, E., Carothers, A. M. & Chasin, L. A. Cell 33, 405–412 (1983).
Kelley, K., Cochran, B. H., Stiles, C. D. & Leder, P. Cell 35, 603–610 (1983).
Hackett, R. W. & Lis, J. T. Proc. natn. Acad. Sci. U.S.A. 78, 6196–6200 (1981).
Ralston, R. & Bishop, J. M. Nature 306, 803–806 (1983).
Ruley, H. E. Nature 304, 602–607 (1983).
Nevins, J. R. Cell 29, 913–919 (1982).
Berk, A. J., Lee, F., Harrison, T., Williams, J. & Sharp, P. A. Cell 17, 935–944 (1979).
Bos, J. L. & ten Wolde-Kraamwinkel, H. C. EMBO J. 2, 73–76 (1983).
Elkaim, R., Coding, C. & Kedinger, C. Nucleic Acids Res. 11, 7105–7117 (1983).
Gaynor, R. B., Hillman, D. & Berk, A. J. Proc. natn. Acad. Sci. U.S.A. 81, 1193–1197 (1984).
Green, M. R., Treisman, R. & Maniatis, T. Cell 35, 137–148 (1983).
Treisman, R., Green, M. R. & Maniatis, T. Proc. natn. Acad. Sci. U.S.A. 80, 7428–7432 (1983).
Maxam, A. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).
Graham, F. L. & van der Eb, A. J. Virology 52, 456–467 (1973).
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Kingston, R., Baldwin, A. & Sharp, P. Regulation of heat shock protein 70 gene expression by c-myc. Nature 312, 280–282 (1984). https://doi.org/10.1038/312280a0
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DOI: https://doi.org/10.1038/312280a0
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