Abstract
Horizontal cells mediate lateral transmission of signals in the outer plexiform layer of the vertebrate retina, and are presumed to contribute to surround properties of photoreceptors and bipolar cells by chemical transmission. The cell bodies1 and dendrites2 of fish horizontal cells possess presynaptic specializations characteristic of conventional chemical synapses. Horizontal cell axon terminals have not so far been shown to contain presynaptic specializations nor have the targets of the somatic and dendritic synapses been fully characterized. Using electron microscope autoradiography of retinas labelled by high-affinity 3H-glycine uptake, we show here that goldfish horizontal cells make somatodendritic and axodendritic synapses on glycinergic interplexiform cells (Gly-IPCs) as apposed to dopaminergic interplexiform cells. Thus, horizontal cells have at least three postsynaptic targets: photoreceptors, bipolar cells and Gly-IPCs. Gly-IPCs may constitute a major alternative pathway for horizontal cell signals to reach the inner plexiform layer.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Witkovsky, P. & Dowling, J. E. Z. Zellforsch. 100, 60–82 (1969).
Sakai, H. & Naka, K.-I. Vision Res. 23, 339–351 (1983).
Marc, R. E. & Lam, D. M. K. J. Neurosci. 1, 152–165 (1981).
Marc, R. E. Vision Res. 22, 589–608 (1982).
Marc, R. E. in Retinal Transmitters and Modulators: Models for the Brain Vol. 1 (ed. Morgan, W. W.) (CRC Press, Boca Raton, Florida, in the press).
Rayborn, M. E., Sarthy, P. V., Lam, D. M. K. & Hollyfield, J. G. J. comp. Neurol. 195, 585–593 (1981).
Marshak, D. & Dowling, J. Soc. Neurosci. Abstr. 10, 21 (1984).
Lam, D. M. K. Nature 254, 345–347 (1975).
Lam, D. M. K. & Steinman, L. Proc. natn. Acad. Sci. U.S.A. 68, 2777–2781 (1971).
Marc, R. E., Stell, W. K., Bok, D. & Lam, D. J.K. J. comp. Neurol. 182, 221–245 (1978).
Lam, D. M. K. et al. Nature 278, 565–567 (1979).
Murakami, M., Shimoda, Y. & Nakatani, K. Sensory Processes 2, 334–338 (1978).
Murakami, M., Shimoda, Y., Nakatani, K., Miyashi, E.-I. & Watanabe, S.-I. Jap. J. Physiol. 32, 911–926 (1982).
Stell, W. K. & Lightfoot, D. O. J. comp. Neurol. 159, 473–502 (1975).
Kaneko, A. J. Physiol., Lond. 207, 623–633 (1970).
Mitarai, G., Asano, T. & Miyake, Y. Jap. J. Ophthal. 18, 161–176 (1974).
Hashimoto, Y., Kata, A., Inokuchi, M. & Watanabe, K. Vision Res. 16, 25–30 (1976).
Curtis, D. R. & Johnston, G. A. R. Ergebn. Physiol. 69, 97–188 (1974).
Matthews, G. & Wickelgren, W. O. J. Physiol., Lond. 293, 393–415 (1979).
Miller, R. F., Frumkes, T. E., Slaughter, M. & Dacheux, R. F. J. Neurophysiol. 45, 743–763 (1981).
Naka, K.-I., Marmarelis, P. Z. & Chan, R. Y. J. Neurophysiol. 38, 92–131 (1975).
Davis, W. & Naka, K.-I. J. Neurophysiol. 43, 807–831 (1980).
Dowling, J. E. & Ehinger, B. Proc. R. Soc. B207, 7–26 (1978).
Dowling, J. E. & Werblin, F. S. J. Neurophysiol. 32, 315–338 (1969).
Dowling, J. E., Brown, J. E. & Major, D. Science 153, 1639–1641 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Marc, R., Liu, WL. Horizontal cell synapses onto glycine-accumulating interplexiform cells. Nature 312, 266–269 (1984). https://doi.org/10.1038/312266a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/312266a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
