Abstract
Analysis of three new T-cell receptor β-chain variable regions together with those in the literature indicates that they have both remarkable similarities and differences with those of immunoglobulin. Less than 10 V regions appear to predominate in the thymus. Vβ sequences are much more heterogeneous at the amino acid level than are immunoglobulin V regions and they appear to diverge between species much more quickly, apparently the result of additional hypervariable regions. Three of these putative new hypervariable regions lie outside of the classical immunoglobulin binding site, an indication that important interactions may be occurring in these regions with polymorphic MHC determinants.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hedrick, S. M., Cohen, D. I., Nielsen, E. A. & Davis, M. M. Nature 308, 149–153 (1984).
Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I. & Davis, M. M. Nature 308, 153–158 (1984).
Yanagi, Y. et al. Nature 308, 145–149 (1984).
Chien, Y., Gascoigne, N. R. J., Kavaler, J., Lee, N. E. & Davis, M. M. Nature 309, 322–326 (1984).
Siu, G. et al. Cell 37, 393–401 (1984).
Gascoigne, N. R. J., Chien, Y., Becker, D. M., Kavaler, J. & Davis, M. M. Nature 310, 387–391 (1984).
Kavaler, J., Davis, M. M. & Chien, Y. Nature 310, 421–423 (1984).
Malissen, M. et al. Cell 37, 1101–1110 (1984).
Siu, G. et al. Nature 311, 344–350 (1984).
Acuto, O. et al. Proc. natn. Acad. Sci. U.S.A. 81, 3851–3855 (1984).
Zinkernagel, R. M. & Doherty, P. C. Adv. Immun. 27, 51–177 (1979).
Bevan, M. & Fink, P. Immun. Rev. 42, 3–19 (1978).
Wu, T. T. & Kabat, E. A. J. exp. Med. 132, 211–250 (1970).
Fresno, M., Nabel, G., McVay-Boudreau, L., Furthmayer, H. & Cantor, H. J. exp. Med. 153, 1246–1259 (1981).
Clayberger, C., Dekruyff, R. H., Aisenberg, J. & Cantor, H. J. exp. Med. 157, 1906–1919 (1983).
Giedlin, M., Longenecker, B. & Mosmann, T. (submitted).
Okayama, H. & Berg, P. Molec. Cell. Biol. 2, 161–170 (1982).
Okayama, H. & Berg, P. Molec. cell. Biol. 3, 280–289 (1983).
Davis, M. M., Chien, Y., Gascoigne, N. R. J. & Hedrick, S. M. Immun. Rev. 81, 233–255 (1984).
Rao, A. et al. Cell 36, 879–888 (1984).
Hedrick, S. M. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Maxam, A. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).
Saito, H. et al. Nature 309, 757–762 (1984).
Chien, Y., Kavaler, J. & Davis, M. M. Proc. natn. Acad. Sci. U.S.A. (submitted).
Kabat, E. A., Wu, T. T., Bilofsky, H., Reid-Miller, M. & Perry, H. Sequences of Immunological interest (US Dept of Health and Human Services, Washington, D. C., 1983).
Nakanishi, K. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6984–6988 (1982).
Kraig, E. et al. J. exp. Med. 158, 192–209 (1983).
Kronenberg, M. et al. J. exp. Med. 158, 210–227 (1983).
Huynh, T. V., Young, R. A. & Davis, R. W. in DNA Cloning Techniques: A Practical Approach (ed. Glover, D. M.) (IRL, Oxford, 1984).
Melchers, I. J. exp. Med. 156, 1587–1603 (1982).
Hamann, U. et al. J. Immun. 130, 7–14 (1983).
Capra, J. D. et al. Proc. natn. Acad. Sci. U.S.A. 71, 845–848 (1974).
Litman, G. et al. Nature 303, 349–352 (1983).
Gojobori, T. & Nei, M. Molec. biol. Evol. 1, 195–212 (1984).
Crews, S. et al. Cell 25, 59–66 (1981).
Dickerson, R. & Geis, I. Hemoglobin: Structure, Function, Evolution, and Pathology (Benjamin/Cummings, Menlo Park, 1983).
Romer, A. Vertebrate Paleontology (University of Chicago Press, Chicago, 1966).
Litman, G. et al. Nucleic Acids Res. 10, 3371–3380 (1982).
Bentley, D. et al. Cell 24, 613–623 (1981).
Brodeur, P. & Riblet, R. (in preparation).
Cory, S. et al. J. molec. appl. Genet. 1, 103–116 (1981).
Chou, P. & Fasman, G. A. Rev. Biochem. 47, 251–276 (1978).
Davies, D. & Metzger, H. A. Rev. Immun. 1, 87–117 (1983).
Kappler, J. W., Skidmore, B., White, J. & Marrack, P. J. exp. Med. 153, 1198–1214 (1981).
Heber-Katz, E. et al. J. exp. Med. 155, 1086–1099 (1982).
Hunig, T. R. & Bevan, M. J. J. exp. Med. 155, 11–125 (1982).
Maniatis, T., Fritsch, E. & Sambrook, J. in Molecular Cloning, A Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Patten, P., Yokota, T., Rothbard, J. et al. Structure, expression and divergence of T-cell receptor β-chain variable regions. Nature 312, 40–46 (1984). https://doi.org/10.1038/312040a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/312040a0
This article is cited by
-
Omics in gut microbiome analysis
Journal of Microbiology (2021)
-
TCRJ and BCRJ gene segments contain 5′ D-segment sequences that contribute to repertoire diversity
Immunogenetics (2009)
-
Induction of Neonatal Tolerance to Oxidized Lipoprotein Reduces Atherosclerosis In ApoE Knockout Mice
Molecular Medicine (2000)
-
Germline genomic structure of the B10.A mouseTcra-V2 gene subfamily
Immunogenetics (1996)
-
Immunopathogenesis of juvenile rheumatoid arthritis: Role of T cells and MHC
Immunologic Research (1995)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.