Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Lack of association between intrachromosomal gene conversion and reciprocal exchange

Nature volume 310, pages 748–753 (1984)Cite this article

Abstract

The association of reciprocal exchange with intrachromosomal gene conversion has been examined using an inverted repeat at the HIS3 locus of Saccharomyces cerevisiae. Intrachromosomal gene conversions between the duplicated inverted sequences are frequent In contrast to gene conversion events between homologous chromosomes, intrachromosomal gene conversion is not associated with reciprocal exchange in flanking sequences. This observation has important consequences for the role of gene conversion in the maintenance of multigene families.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Jackson, J. A. & Fink, G. R. Nature 292, 306–311 (1981).

    Article  ADS  CAS  Google Scholar 

  2. Klein, H. L. & Petes, T. D. Nature 289, 144–148 (1981).

    Article  ADS  CAS  Google Scholar 

  3. Baltimore, D. Cell 24, 592–594 (1981).

    Article  CAS  Google Scholar 

  4. Bothwell, A. L. M. et al. Cell 24, 625–637 (1981).

    Article  CAS  Google Scholar 

  5. Dover, G. Nature 299, 111–117 (1982).

    Article  ADS  CAS  Google Scholar 

  6. Lamb, B. C. & Helmi, S. Genet. Res. 39, 199–217 (1982).

    Article  Google Scholar 

  7. Liebhaber, S. A., Goosens, M. & Kan, Y. W. Nature 290, 26–29 (1981).

    Article  ADS  CAS  Google Scholar 

  8. Slightom, J. L., Blechl, A. E. & Smithies, O. Cell 21, 627–638 (1980).

    Article  CAS  Google Scholar 

  9. Fogel, S. & Hurst, D. D. Genetics 57, 455–481 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Fogel, S., Mortimer, R. K., Lusnak, K. & Tavares, F. Cold Spring Harb. Symp. quant. Biol. 43, 1325–1341 (1979).

    Article  CAS  Google Scholar 

  11. Hurst, D. D., Fogel, S. & Mortimer, R. K. Proc. natn. Acad. Sci. U.S.A. 69, 101–105 (1972).

    Article  ADS  CAS  Google Scholar 

  12. Mitchell, M. B. Proc. natn. Acad. Sci. U.S.A. 41, 215–220 (1955).

    Article  ADS  CAS  Google Scholar 

  13. Stadler, D. R. A. rev. Genet. 7, 113–127 (1973).

    Article  CAS  Google Scholar 

  14. Fogel, S., Mortimer, R. K. & Lusnak, K. in The Molecular Biology of the Yeast Saccharomyces : Life Cycle and Inheritance (eds Strathern, J. N., Jones, E. W. & Broach, J. R.) 289–339 (Cold Spring Harbor Laboratory, New York, 1981).

    Google Scholar 

  15. DiCaprio, L. & Hastings, P. J. Genetics 84, 697–721 (1976).

    PubMed Central  Google Scholar 

  16. Sang, H. & Whitehouse, H. L. K. Molec. gen. Genet. 174, 327–334 (1979).

    Article  Google Scholar 

  17. Hinnen, A., Hicks, J. B. & Fink, G. R. Proc. natn. Acad. Sci. U.S.A. 75, 1929–1933 (1978).

    Article  ADS  CAS  Google Scholar 

  18. Struhl, K., Stinchcomb, D. T., Scherer, S. & Davis, R. W. Proc. natn. Acad. Sci. U.S.A. 76, 1035–1039 (1979).

    Article  ADS  CAS  Google Scholar 

  19. Struhl, K. & Davis, R. W. J. molec. Biol. 136, 309–332 (1980).

    Article  CAS  Google Scholar 

  20. Orr-Weaver, T. L., Szostak, J. W. & Rothstein, R. J. Proc. natn. Acad. Sci U.S.A. 78, 6354–6358 (1981).

    Article  ADS  CAS  Google Scholar 

  21. Struhl, K. & Davis, R. W. J. molec. Biol. 152, 535–552 (1981).

    Article  CAS  Google Scholar 

  22. Mikus, M. D. & Petes, T. D. Genetics 101, 369–404 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Haber, J. E., Rogers, D. T. & McCusker, J. H. Cell 22, 277–289 (1980).

    Article  CAS  Google Scholar 

  24. Hawthorne, D. C. Genetics 48, 1727–1729 (1963).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Klar, A. J. S., Strathern, J. N., Hicks, J. B. & Prudente, D. Molec. cell. Biol. 3, 803–810 (1983).

    Article  CAS  Google Scholar 

  26. Strathern, J. N., Newlon, C. S., Herskowitz, I. & Hicks, J. B. Cell 18, 309–320 (1979).

    Article  CAS  Google Scholar 

  27. Strathern, J. N., Spatola, E., McCrill, C. & Hicks, J. B. Proc. natn. Acad. Sci. U.S.A. 77, 2829–2843 (1980).

    Article  ADS  Google Scholar 

  28. Klar, A. J. S. & Strathern, J. N. Nature 310, 744–748 (1984).

    Article  ADS  CAS  Google Scholar 

  29. Sigal, N. & Alberts, B. J. molec. Biol. 71, 789–793 (1972).

    Article  CAS  Google Scholar 

  30. Meselson, M. S. & Radding, C. M. Proc. natn. Acad. Sci. U.S.A. 72, 358–361 (1975).

    Article  ADS  CAS  Google Scholar 

  31. Sobell, H. M. in Molecular Mechanisms in Genetics Recombination (ed. Grell, R. F.) 433–438 (Oak Ridge Symp., Plenum New York, 1974).

    Book  Google Scholar 

  32. Holmes, D. S. & Quigley, M. Analyt. Biochem. 114, 193–197 (1981).

    Article  CAS  Google Scholar 

  33. Birnboim, H. C. & Doly, J. Nucleic Acids Res. 7, 1513–1523 (1979).

    Article  CAS  Google Scholar 

  34. Clewell, D. & Helinski, D. Biochem. 9, 4428–4440 (1970).

    Article  CAS  Google Scholar 

  35. Mandel, M. & Higa, A. J. molec. Biol. 53, 154–162 (1970).

    Article  Google Scholar 

  36. Sherman, F., Fink, G. R. & Hicks, J. B. Methods in Yeast Genetics (Cold Spring Harbor Laboratory, New York, 1981).

    Google Scholar 

  37. Southern, E. J. molec. Biol. 98, 503–518 (1975).

    Article  CAS  Google Scholar 

  38. Schachat, F. W. & Hogness, D. S. Cold Spring Harb. Symp. quant. Biol. 38, 371–381 (1973).

    Article  Google Scholar 

  39. Denhardt, D. Biochem. biophys. Res. Commun. 23, 641–652 (1966).

    Article  CAS  Google Scholar 

  40. Laskey, R. A. & Mills, D. FEBS Lett. 82, 314–316 (1977).

    Article  CAS  Google Scholar 

  41. Sugawara, N. & Szostak, J. W. Proc. natn. Acad. Sci. U.S.A. 80, 5675–5679 (1983).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, New York University Medical Center, 550 First Avenue, New York, New York, 10016, USA

    Hannah L. Klein

Authors
  1. Hannah L. Klein
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Klein, H. Lack of association between intrachromosomal gene conversion and reciprocal exchange. Nature 310, 748–753 (1984). https://doi.org/10.1038/310748a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/310748a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing