Abstract
The association of reciprocal exchange with intrachromosomal gene conversion has been examined using an inverted repeat at the HIS3 locus of Saccharomyces cerevisiae. Intrachromosomal gene conversions between the duplicated inverted sequences are frequent In contrast to gene conversion events between homologous chromosomes, intrachromosomal gene conversion is not associated with reciprocal exchange in flanking sequences. This observation has important consequences for the role of gene conversion in the maintenance of multigene families.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Jackson, J. A. & Fink, G. R. Nature 292, 306–311 (1981).
Klein, H. L. & Petes, T. D. Nature 289, 144–148 (1981).
Baltimore, D. Cell 24, 592–594 (1981).
Bothwell, A. L. M. et al. Cell 24, 625–637 (1981).
Dover, G. Nature 299, 111–117 (1982).
Lamb, B. C. & Helmi, S. Genet. Res. 39, 199–217 (1982).
Liebhaber, S. A., Goosens, M. & Kan, Y. W. Nature 290, 26–29 (1981).
Slightom, J. L., Blechl, A. E. & Smithies, O. Cell 21, 627–638 (1980).
Fogel, S. & Hurst, D. D. Genetics 57, 455–481 (1967).
Fogel, S., Mortimer, R. K., Lusnak, K. & Tavares, F. Cold Spring Harb. Symp. quant. Biol. 43, 1325–1341 (1979).
Hurst, D. D., Fogel, S. & Mortimer, R. K. Proc. natn. Acad. Sci. U.S.A. 69, 101–105 (1972).
Mitchell, M. B. Proc. natn. Acad. Sci. U.S.A. 41, 215–220 (1955).
Stadler, D. R. A. rev. Genet. 7, 113–127 (1973).
Fogel, S., Mortimer, R. K. & Lusnak, K. in The Molecular Biology of the Yeast Saccharomyces : Life Cycle and Inheritance (eds Strathern, J. N., Jones, E. W. & Broach, J. R.) 289–339 (Cold Spring Harbor Laboratory, New York, 1981).
DiCaprio, L. & Hastings, P. J. Genetics 84, 697–721 (1976).
Sang, H. & Whitehouse, H. L. K. Molec. gen. Genet. 174, 327–334 (1979).
Hinnen, A., Hicks, J. B. & Fink, G. R. Proc. natn. Acad. Sci. U.S.A. 75, 1929–1933 (1978).
Struhl, K., Stinchcomb, D. T., Scherer, S. & Davis, R. W. Proc. natn. Acad. Sci. U.S.A. 76, 1035–1039 (1979).
Struhl, K. & Davis, R. W. J. molec. Biol. 136, 309–332 (1980).
Orr-Weaver, T. L., Szostak, J. W. & Rothstein, R. J. Proc. natn. Acad. Sci U.S.A. 78, 6354–6358 (1981).
Struhl, K. & Davis, R. W. J. molec. Biol. 152, 535–552 (1981).
Mikus, M. D. & Petes, T. D. Genetics 101, 369–404 (1982).
Haber, J. E., Rogers, D. T. & McCusker, J. H. Cell 22, 277–289 (1980).
Hawthorne, D. C. Genetics 48, 1727–1729 (1963).
Klar, A. J. S., Strathern, J. N., Hicks, J. B. & Prudente, D. Molec. cell. Biol. 3, 803–810 (1983).
Strathern, J. N., Newlon, C. S., Herskowitz, I. & Hicks, J. B. Cell 18, 309–320 (1979).
Strathern, J. N., Spatola, E., McCrill, C. & Hicks, J. B. Proc. natn. Acad. Sci. U.S.A. 77, 2829–2843 (1980).
Klar, A. J. S. & Strathern, J. N. Nature 310, 744–748 (1984).
Sigal, N. & Alberts, B. J. molec. Biol. 71, 789–793 (1972).
Meselson, M. S. & Radding, C. M. Proc. natn. Acad. Sci. U.S.A. 72, 358–361 (1975).
Sobell, H. M. in Molecular Mechanisms in Genetics Recombination (ed. Grell, R. F.) 433–438 (Oak Ridge Symp., Plenum New York, 1974).
Holmes, D. S. & Quigley, M. Analyt. Biochem. 114, 193–197 (1981).
Birnboim, H. C. & Doly, J. Nucleic Acids Res. 7, 1513–1523 (1979).
Clewell, D. & Helinski, D. Biochem. 9, 4428–4440 (1970).
Mandel, M. & Higa, A. J. molec. Biol. 53, 154–162 (1970).
Sherman, F., Fink, G. R. & Hicks, J. B. Methods in Yeast Genetics (Cold Spring Harbor Laboratory, New York, 1981).
Southern, E. J. molec. Biol. 98, 503–518 (1975).
Schachat, F. W. & Hogness, D. S. Cold Spring Harb. Symp. quant. Biol. 38, 371–381 (1973).
Denhardt, D. Biochem. biophys. Res. Commun. 23, 641–652 (1966).
Laskey, R. A. & Mills, D. FEBS Lett. 82, 314–316 (1977).
Sugawara, N. & Szostak, J. W. Proc. natn. Acad. Sci. U.S.A. 80, 5675–5679 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Klein, H. Lack of association between intrachromosomal gene conversion and reciprocal exchange. Nature 310, 748–753 (1984). https://doi.org/10.1038/310748a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/310748a0
This article is cited by
-
Tandem repeats derived from centromeric retrotransposons
BMC Genomics (2013)
-
Genetic evidence for different RAD52-dependent intrachromosomal recombination pathways in Saccharomyces cerevisiae
Current Genetics (1995)
-
Increase in incidence of chromosome instability and non-conservative recombination between repeats in Saccharomyces cerevisiae hpr1Δ strains
Molecular and General Genetics MGG (1994)
-
Gene conversion in the Escherichia coli RecF pathway: a successive half crossing-over model
Molecular and General Genetics MGG (1992)
-
Gene conversions within the Cup1 r region from heterologous crosses in Saccharomyces cerevisiae
Molecular and General Genetics MGG (1991)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.