Abstract
In BALB/c-3T3 cells, expression of the c-myc gene is stimulated by platelet-derived growth factor (PDGF). Using mouse mammary tumour virus promoter: c-myc recombinant plasmids, 3T3 sublines were constructed in which hydrocortisone was the primary determinant of myc mRNA content. The c-myc gene product is an intracellular mediator of the growth response to PDGF though probably not the only one. Both the human and the mouse c-myc genes stimulate clonal growth of 3T3 cells in PDGF-free medium suggesting new strategies for analysis of oncogenes which do not function in focus formation assays.
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Armelin, H., Armelin, M., Kelly, K. et al. Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature 310, 655–660 (1984). https://doi.org/10.1038/310655a0
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DOI: https://doi.org/10.1038/310655a0
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