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Brain grafts can restore irradiation-damaged neuronal connections in newborn rats

Nature volume 310, pages 51–53 (1984)Cite this article

Abstract

Immature rat brain tissue grafted to the brain of other immature and adult rats can survive and establish nerve connections with the host brains1–5. In addition to facilitating the study of factors involved in the formation of central neural connections, brain grafts may also be used to substitute damaged or maldeveloped neurones5–10. With exceptions in the visual system5, the restoration of specific central neural connections has to date involved grafts of cholinergic and monoaminergic neurones, which have good regenerative capacity10. In the present study, rat hippocampal neurones were damaged by neonatal X-ray irradiation and replaced by transplantation of normal, developing neurones of the same type. The grafted neurones (dentate granule cells) are not cholinergic or monoaminergic, but when appropriately located in the host hippocampal region they established specific and highly ordered afferent and efferent connections with the damaged host brain. Moreover, simultaneous demonstration of afferent and efferent transplant pathways showed that serial host–transplant–host connections had formed, restoring the normal neuronal circuitry initially disrupted by the irradiation.

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References

  1. Lund, R. D. & Hauschka, S. D. Science 193, 582–584 (1976).

    Article  ADS  CAS  Google Scholar 

  2. Björklund, A. & Stenevi, U. Cell Tissue Res. 186, 289–302 (1977).

    Google Scholar 

  3. Oblinger, M. M., Kallas, B. H. & Das, G. D. Brain Res. 189, 228–232 (1980).

    Article  CAS  Google Scholar 

  4. Sunde, N., & Zimmer, J. Devl Brain Res. 8, 165–191 (1983).

    Article  Google Scholar 

  5. Lund, R. D. & McLoon, S. C. in Neural Tissue Transplantation Research (eds Walles, R. B. & Das, G. D.) 165–174 (Springer, New York, 1981).

    Google Scholar 

  6. Björklund, A. & Stvenevi, U. Brain Res. 177, 555–560 (1979).

    Article  Google Scholar 

  7. Gash, D., Sladek, J. R. Jr & Sladek, C. D. Science 210, 1367–1369 (1980).

    Article  ADS  CAS  Google Scholar 

  8. Krieger, D. T. et al. Nature 298, 468–471 (1982).

    Article  ADS  CAS  Google Scholar 

  9. Low, W. C. et al. Nature 300, 260–262 (1982).

    Article  ADS  CAS  Google Scholar 

  10. Björklund, A. et al. Acta physiol. scand. Suppl 522, 1–75 (1983).

    Google Scholar 

  11. Hjorth-Simonsen, A. & Jeune, B. J. comp. Neurol. 144, 215–232 (1972).

    Article  CAS  Google Scholar 

  12. Hjorth-Simonsen, A. J. comp. Neurol. 146, 219–232 (1972).

    Article  CAS  Google Scholar 

  13. Steward, O. J. comp. Neurol. 167, 285–314 (1976).

    Article  CAS  Google Scholar 

  14. Zimmer, J. J. comp. Neurol. 142, 393–416 (1971).

    Article  CAS  Google Scholar 

  15. Laurberg, S. J. comp. Neurol. 184, 685–708 (1979).

    Article  CAS  Google Scholar 

  16. Blackstad, T. W., Brink, K., Hem, J. & Jeune, B. J. comp. Neurol. 138, 433–450 (1970).

    Article  CAS  Google Scholar 

  17. Gaarskjaer, F. B. J. comp. Neurol. 203, 717–735 (1981).

    Article  CAS  Google Scholar 

  18. Haug, F.-M. S., Blackstad, T. W., Simonsen, A.H. & Zimmer, J. J. comp. Neurol. 142, 23–32 (1971).

    Article  CAS  Google Scholar 

  19. Zimmer, J. Prog. Brain Res. 48, 171–189 (1978).

    Article  CAS  Google Scholar 

  20. Bayer, S. A. J. comp. Neurol. 190, 87–114 (1980).

    Article  CAS  Google Scholar 

  21. Bayer, S. A. & Altman, J. J. comp. Neurol. 163, 1–20 (1975).

    Article  Google Scholar 

  22. Laurberg, S. & Hjorth-Simonsen, A. Nature 269, 158–160 (1977).

    Article  ADS  CAS  Google Scholar 

  23. Geneser-Jensen, F. A. & Blackstad, T. W. Z. Zellforsch. 115, 460–481 (1971).

    Article  Google Scholar 

  24. Cowan, W. M., Stanfield, B. B. & Amaral, D. G. in Studies in Developmental Neurobiology (ed. Cowan, W. M.) 395–435 (Oxford University Press, 1981).

    Google Scholar 

  25. Stirling, R. V. & Bliss, T. V. P. Prog. Brain Res. 48, 191–198 (1978).

    Article  CAS  Google Scholar 

  26. Gottlieb, D. I. & Cowan, W. M. Brain Res. 41, 452–456 (1972).

    Article  CAS  Google Scholar 

  27. Sunde, N. & J. Neurosci. Lett. Suppl. 7, S33 (1981).

    Google Scholar 

  28. Raisman, G. & Ebner, F. F. Neuroscience 9, 783–801 (1983).

    Article  CAS  Google Scholar 

  29. Bayer, S., Brunner, R. L., Heni, R. & Altman, J. Nature 242, 222–224 (1973).

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Anatomy B (Neurobiology), University of Aarhus, DK-8000, Aarhus C, Denmark

    N. Sunde, S. Laurberg & J. Zimmer

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  1. N. Sunde
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  2. S. Laurberg
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  3. J. Zimmer
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Sunde, N., Laurberg, S. & Zimmer, J. Brain grafts can restore irradiation-damaged neuronal connections in newborn rats. Nature 310, 51–53 (1984). https://doi.org/10.1038/310051a0

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