Abstract
Two related, but distinct, cDNA clones have been isolated and sequenced from a functional murine cytotoxic T-lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and both have similarities to immunoglobulin variable and constant region genes. It is concluded that these genes code for the two subunits of the heterodimeric antigen receptor on the surface of the T cell; its complete deduced primary structure is presented.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Kindred, B. & Shreffler, D. C. J. Immun. 109, 940–943 (1972).
Katz, D. H., Hamaoka, T., Dorf, M. E., Maurer, P. H. & Benacerraf, B. J. exp. Med. 138, 734–739 (1973).
Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).
Zinkernagel, R. M. et al. J. exp. Med. 147, 882–896 (1978).
Fink, P. J. & Bevan, M. J. J. exp. Med. 148, 766–775 (1978).
Tonegawa, S. Nature 302, 575–581 (1983).
Jensenius, J. C. & Williams, A. F., Nature 300, 583–588 (1982).
Allison, J. P., McIntyre, B. W. & Bloch, D. J. Immun. 129, 2293–2300 (1982).
Meuer, S. C. et al. J. exp. Med. 157, 705–719 (1983).
Haskins, K. et al. J. exp. Med. 157, 1149–1169 (1983).
Acuto, O. et al. Cell 34, 717–726 (1983).
McIntyre, B. W. & Allison, J. P. Cell 34, 739–746 (1983).
Kappler, J. et al. Cell 35, 295–302 (1983).
Yanagi, Y. et al. Nature 308, 145–149 (1984).
Hedrick, S. M., Cohen, D. I., Nielsen, E. A. & Davis, M. M. Nature, 308, 149–153 (1984).
Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I. & Davis, M. M. Nature 308, 153–158 (1984).
Kranz, D. M., Sherman, D. H., Sitkovsky, M. V., Pasternack, M. S. & Eisen, H. N. Proc. natn. Acad. Sci. U.S.A. 81, 573–577 (1984).
McKean, D. J. et al. J. exp. Med. 154, 1419–1431 (1981).
Lynes, M. A., Lanier, L. L., Babcock, G. F., Wettstein, P. J. & Haughton, G. J. Immun. 121, 2352–2357 (1978).
Maxam, A. M. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).
Chien Yih., Gascoigne, N. R. J., Kavaler, J., Lee, N. E. & Davis, M. M. Nature 309, 322–326 (1984).
Blobel, G. & Dobberstein, B. J. Cell Biol. 67, 834–851 (1975).
Kabat, E. A., Wu, T. T., Bilofsky, H., Reid-Miller, M. & Perry, H. in Proteins of Immunological Interest (National Institutes of Health, Bethesda, 1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Saito, H., Kranz, D., Takagaki, Y. et al. Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature 309, 757–762 (1984). https://doi.org/10.1038/309757a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/309757a0
This article is cited by
-
γδ T cells: origin and fate, subsets, diseases and immunotherapy
Signal Transduction and Targeted Therapy (2023)
-
Local γδ T cells: translating promise to practice in cancer immunotherapy
British Journal of Cancer (2023)
-
γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer
Nature Reviews Cancer (2019)
-
A cold-blooded view of adaptive immunity
Nature Reviews Immunology (2018)
-
Determination of Anti-Anisakis Simplex Antibodies and Relationship with αβ and γδ Lymphocyte Subpopulations in Patients with Crohn’s Disease
Digestive Diseases and Sciences (2017)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.