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Spinal opiates affect sexual behaviour in rats

Nature volume 309, pages 257–258 (1984)Cite this article

Abstract

Enkephalin-containing cells in the substantia gelatinosa of the spinal cord1 participate in the neural processing of painful stimuli2,3. Spinal opiates may also be involved in the perception of sensory stimuli related to reproduction, as probing of the uterine cervix stimulates sexual behaviour in rats4 and also induces an analgesia5 which is partially dependent on opiate receptor mechanisms in the spinal cord6–8. We now report that the intrathecal injection of morphine into female ovariectomized rats pretreated with oestradiol benzoate and progesterone inhibits sexual receptivity while injection of the opiate receptor antagonist naloxone enhances it. Similarly, intrathecal injection of morphine increases while injection of naloxone decreases the number of intromissions before ejaculation in male rat. Intraperitoneal injection of morphine or naloxone has no behavioural effect. Recent studies have suggested that brain opiates are involved in the control of sexual behaviour9–11. The results reported here indicate that sexual behaviour may also be influenced by spinal opiates.

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References

  1. Hökfelt, T. et al. in Brain Stem Control of Spinal Mechanisms (eds Sjölund, B. & Björklund, A.) 89–117 (Elsevier, Amsterdam, 1982).

    Google Scholar 

  2. Yoshimura, M. & North, A. Nature 305, 529–530 (1983).

    Article  ADS  CAS  Google Scholar 

  3. Yaksh, T. & Hammond, D. L. in Brain Stem Control of Spinal Mechanisms (eds Sjölund, B. & Björklund, A.) 437–497 (Elsevier, Amsterdam, 1982).

    Google Scholar 

  4. Komisaruk, B. R. & Diakow, C. Endocrinology 93, 548–557 (1973).

    Article  CAS  Google Scholar 

  5. Komisaruk, B. R. in Brain Stem Control of Spinal Mechanisms (eds Sjölund, B. & Björklund, A.) 493–508 (Elsevier, Amsterdam, 1982).

    Google Scholar 

  6. Henry, J. L. Neurosci. Lett. 38, 257–262 (1983).

    Article  CAS  Google Scholar 

  7. Hill, R. G. & Ayliff, S. J. Pharmac. Biochem. Behav. 14, 631–632 (1981).

    Article  CAS  Google Scholar 

  8. Crowley, W. R., Rodriguez-Sierra, J. F. & Komisaruk, B. R. Psychopharmacology 54, 223–225 (1977).

    Article  CAS  Google Scholar 

  9. Sirinathsinghji, D. J. S., Whittington, P. E., Audsley, A. & Fraser, H. M. Nature 301, 62–64 (1983).

    Article  ADS  CAS  Google Scholar 

  10. Sirinathsinghji, D. J. S., Rees, L. H., Rivier, J. & Wale, V. Nature 305, 232–235 (1983).

    Article  ADS  CAS  Google Scholar 

  11. Wiesner, J. B. & Moss, R. L. Soc. Neurosci. Abstr. 8, 930 (1982).

    Google Scholar 

  12. Yaksh, T. & Rudy, T. A. Physiol. Behav. 17, 1031–1036 (1976).

    Article  CAS  Google Scholar 

  13. Yaksh, T. L. Pain 11, 293–346 (1981).

    Article  CAS  Google Scholar 

  14. Yaksh, T. & Rudy, T. A. J. Pharmac. exp. Ther. 202, 411–428 (1977).

    CAS  Google Scholar 

  15. Dickenson, A. H., Le Bars, D. & Besson, J. M. Neurosci. Lett. 24, 161–164 (1981).

    Article  CAS  Google Scholar 

  16. Woolf, C. J. Brain Res. 189, 593–597 (1980).

    Article  ADS  CAS  Google Scholar 

  17. Kow, L. M. & Pfaff, D. W. J. Neurobiol. 6, 1031–1036 (1976).

    Google Scholar 

  18. Kow, L. M. & Pfaff, D. W. Brain Res. 101, 47–66 (1976).

    Article  CAS  Google Scholar 

  19. Kow, L. M., Montgomery, M. O. & Pfaff, D. W. Brain Res. 123, 75–88 (1977).

    Article  CAS  Google Scholar 

  20. Komisaruk, B. R. in Biological Determinants of Sexual Behaviour (ed. Hutchinson, J. B.) 349–393 (Wiley, New York, 1978).

    Google Scholar 

  21. Lodder, J. & Zeilmaker, G. N. J. comp. physiol. Psychol. 90, 925–929 (1976).

    Article  CAS  Google Scholar 

  22. Larsson, K. in Endocrine Control of Sexual Behaviour (ed. Beyer, C.) 77–163 (Raven, New York, 1979).

    Google Scholar 

  23. Carlsson, S. G. & Larsson, K. Z. Tierpsychol. 21, 854–856 (1964).

    Google Scholar 

  24. Larsson, K. & Södersten, P. Physiol. Behav. 10, 567–571 (1973).

    Article  CAS  Google Scholar 

  25. Nunez, R., Gross, G. H. & Sachs, B. D. Soc. Neurosci. Abstr. 9, 530 (1983).

    Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Neurophysiology, Karolinska Institutet, S-141 86, Huddinge, Sweden

    Z. Wiesenfeld-Hallin

  2. Department of Psychiatry, Karolinska Institutet, S-141 86, Huddinge, Sweden

    P. Södersten

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  1. Z. Wiesenfeld-Hallin
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  2. P. Södersten
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Wiesenfeld-Hallin, Z., Södersten, P. Spinal opiates affect sexual behaviour in rats. Nature 309, 257–258 (1984). https://doi.org/10.1038/309257a0

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