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Alternative transcription and two modes of splicing result in two myosin light chains from one gene

Nature volume 308, pages 333–337 (1984)Cite this article

Abstract

Chicken skeletal muscle myosin alkali light chains are encoded by a single gene of size 18 kilobases (kb). This gene has two transcription initiation sites from which 17.5- and 8-kb precursor RNAs are transcribed. These RNAs are processed by different modes of splicing to form mRNAs encoding distinct light-chain (LC1 and LC3) proteins.

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Author notes

  1. Yo-ichi Nabeshima

    Present address: Friedrich Miescher Institute, Basel, Switzerland

Authors and Affiliations

  1. Department of Biochemistry, Niigata University School of Medicine, Niigata, 951, Japan

    Yo-ichi Nabeshima & Kikuo Ogata

  2. Department of Biochemistry, Cancer Institute, Japanese Foundation for Cancer Research, Kami-Ikebukuro, Toshima-ku, Tokyo, 170, Japan

    Yoshiaki Fujii-Kuriyama

  3. Department of Biochemistry, The University of Tokyo Faculty of Medicine, Hongo, Bunkyo-ku, Tokyo, 113, Japan

    Masami Muramatsu

Authors
  1. Yo-ichi Nabeshima
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  2. Yoshiaki Fujii-Kuriyama
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  3. Masami Muramatsu
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  4. Kikuo Ogata
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Nabeshima, Yi., Fujii-Kuriyama, Y., Muramatsu, M. et al. Alternative transcription and two modes of splicing result in two myosin light chains from one gene. Nature 308, 333–337 (1984). https://doi.org/10.1038/308333a0

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