Abstract
At least three different families of endogenous opioid peptides, the enkephalins, endorphins and dynorphins, are present in the mammalian central nervous system (CNS). Immuno-cytochemical studies have demonstrated their localization in neurones1–8, which supports the view that these peptides may have a role as neurotransmitters or neuromodulators. However, the target cells and cellular processes acted upon by the opioid peptides are still largely unknown. One possible function of neuropeptides, including the opioid peptides, may be presynaptic modulation of neurotransmission in certain neuronal pathways, for example, by inhibition or promotion of neurotransmitter release from the nerve terminals9–12. Here we report that dynorphin and some benzomorphans potently and selectively inhibit the release of (radiolabelled) dopamine from slices of rat corpus striatum, by activating κ-opioid receptors. In contrast, [Leu5]enkephalin and [D-Ala2, D-Leu5]enkephalin selectively inhibit acetylcholine release by activating δ-opioid receptors.
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References
Bloom, F. E. et al. Adv. biochem. Psychopharmac. 18, 89–109 (1978).
Snyder, S. H. & Childers, S. R. A. Rev. Neurosci. 2, 35–64 (1979).
Watson, S. J. et al. Science 216 85–87 (1982).
Vincent, S. R., Hökfelt, T., Christensson, I. & Terenius, L. Neurosci. Lett. 33, 185–190 (1982).
Khachaturian, H. et al. Peptides 3, 941–954 (1982).
Watson, S. J. et al. Proc. natn. Acad. Sci. U.S.A. 80 891–894 (1983).
Weber, E. & Barchas, J. D. Proc. natn. Acad. Sci. U.S.A. 80, 1125–1129 (1983).
Cuello, A. C. Br. med. Bull. 39, 11–16 (1983).
Iwamoto, E. T. & Way, E. L. Adv. biochem. Psychopharmac. 20, 357–407 (1979).
Vaughan, P. F. T. Cell. molec. Biol. 28, 369–382 (1982).
Langer, S. Z. Pharmac. Rev. 32, 337–362 (1980).
Starke, K. A. Rev. Pharmac. Toxicol. 21, 7–30 (1981).
Martin, W. R., Eades, C. G., Thompson, J. A., Huppler, R. E. & Gilbert, P. E. J. Pharmac. exp. Ther. 197, 517–532 (1976).
Lord, J. A. H., Waterfield, A. A., Hughes, J. & Kosterlitz, H. W. Nature 267, 495–499 (1977).
Wüster, M., Schultz, R. & Herz, A. Biochem. Pharmac. 30, 1883–1887 (1981).
Wood, P. L. Neuropharmacology 21, 487–497 (1982).
Paterson, S. J., Robson, L. E. & Kosterlitz, H. W., Br. med. Bull. 39, 31–36 (1983).
Chavkin, C., James, I. F. & Goldstein, A. Science 215, 413–415 (1982).
Yoshimura, K., Huidobro-Toro, J. P. & Way, E. L. Eur. J. Pharmac. 84, 17–24 (1982).
Dray, A. Neuroscience 4, 1407–1439 (1979).
Hattori, T., Singh, U. K. & McGeer, P. L. Brain Res. 102, 164–173 (1976).
Bartholini, G., Stadler, H., Gadea Civia, M. & Lloyd, K. G. Neuropharmacology 15, 515–519 (1976).
Garattini, S., Pujol, J.F. & Samanin, R.S. (eds) Interactions Between Putative Neurotransmitters in the Brain 3–38 (Raven, New York, 1978).
Stoof, J. C., Horn, A. S. & Mulder, A. H. Brain Res. 196, 276–281 (1980).
Hertting, G., Zumstein, A., Jackish, R., Hoffmann, I. & Starke, K. Naunyn-Schmiedebergs Archs Pharmak. 315, 111–117 (1980).
Hughes, J., Kosterlitz, H. W. & Smith, T. W. Br. J. Pharmac. 61, 639–647 (1977).
Yang, H. Y., Hong, J. S. & Costa, E. Neuropharmacology 16, 303–307 (1977).
Simantov, R., Kuhar, M. J., Uhl, G. R. & Snyder, S. H. Proc. natn. Acad. Sci. U.S.A. 74, 2167–2171 (1977).
Goldstein, A. & Ghazarossian, V. E. Proc. natn. Acad. Sci. U.S.A. 77, 6207–6210 (1980).
Höllt, V., Haarmann, I., Bovermann, K., Jericz, M. & Herz, A. Neurosci. Lett. 18, 149–153 (1980).
Schoffelmeer, A. N. M., Wemer, J. & Mulder, A. H. Neurochem. Int. 3, 129–136 (1981).
Mulder, A. H. Prog. Brain Res. 55, 135–156 (1982).
Frankhuyzen, A. L. & Mulder, A. H. Eur. J. Pharmac. 78, 91–97 (1982).
Lubetzki, C., Chesselet, M. F. & Glowinski, J. J. Pharmac. exp. Ther. 222, 435–440 (1982).
Szerb, J. C. Eur. J. Pharmac. 29, 192–194 (1974).
Arbilla, S. & Langer, S. Z. Nature 271, 559–561 (1978).
Starr, M. J. pharm. Pharmac. 30, 359–363 (1978).
Beani, L., Bianchi, C. & Siniscalchi, A. Br. J. Pharmac. 76, 393–401 (1982).
Celsen, B. & Kuschinsky, K. Naunyn-Schmiedebergs Archs Pharmak. 284, 159–165 (1974).
Taube, H. D., Starke, K. & Borowski, E. Naunyn-Schmiedebergs Archs Pharmak. 299, 123–141 (1977).
Göthert, M., Pohl, I. M. & Wehking, E. Naunyn-Schmiedebergs Archs Pharmak. 307, 21–27 (1979).
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Mulder, A., Wardeh, G., Hogenboom, F. et al. κ and δ-opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release. Nature 308, 278–280 (1984). https://doi.org/10.1038/308278a0
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DOI: https://doi.org/10.1038/308278a0
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